Axon Guidance

Axon guidance refers to the process by which growing neural axons follow specific, predictable paths to reach their target locations. The tip of the growing axon is known as the growth cone and it is this part of the axon that senses guidance cues (also known as guidance factors) in the surrounding environment. The growth cone receptors respond to the various fixed and diffusible guidance cues and their gradients and respond accordingly. The response is in the form of directional changes in axon growth mediated by cytoskeletal changes. A broad array of signals can function as guidance cues, some of the most well-studied being Netrins, Ephrins and Semaphorins. Each guidance factor serves to attract or repel growth cones during neural development, although different cues can have diverse effects on distinct growth cones. It is the collective influence of the various cues that helps guide axons to their appropriate targets during development. The effects of guidance cues on axon growth can readily be studied in vitro with an array of commercially available factors. Elucidation of the processes that promote and inhibit axon growth during development may provide critical insights into neuroregenerative processes that could benefit patients with spinal cord injuries and other diseases of the nervous system[1].

1. Harel NY and Strittmatter SM. 2006. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci. Aug;7(8):603-16. See Related Product List Below Pathway Image

Axon Guidance pathway image by Aviva System Biology

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  1. HRAS Antibody (OASA02910)
    HRAS Antibody (OASA02910)
    Catalog #: OASA02910
    Protein Name: GTPase HRas
    Alias: CTLO, HAMSV, HRAS1, K-RAS, N-RAS, RASH1, C-H-RAS, H-RASIDX, C-BAS/HAS, C-HA-RAS1, HRAS
    Clone: H-Ras-03
    Predicted Species: Human, Mouse, Rat
    Application: WB
    Format: Purified IgG - liquid
    Size: 0.1 mg
    Price:
    $359.00
  2. MET Antibody (OASA02621)
    MET Antibody (OASA02621)
    Catalog #: OASA02621
    Protein Name: Hepatocyte growth factor receptor
    Alias: HGFR, AUTS9, RCCP2, c-Met, MET
    Clone: 4AT44
    Predicted Species: Human
    Application: WB
    Format: Purified IgG - liquid
    Size: 0.1 mg
    Price:
    $1,219.00
  3. SEMA7A Antibody (OASA02604)
    SEMA7A Antibody (OASA02604)
    Catalog #: OASA02604
    Protein Name: Semaphorin-7A
    Alias: JMH, CD108, SEMAL, CDw108, SEMAK1, H-Sema-L, H-SEMA-K1, MGC126692, MGC126696, SEMA7A
    Clone: MEM-150
    Predicted Species: Human
    Application: FC, IP, WB
    Format: Purified IgM - liquid
    Size: 0.2mg
    Price:
    $545.00
  4. Human peripheral blood lymphocytes
    SEMA4D Antibody (OASA01062)
    Catalog #: OASA01062
    Protein Name: Semaphorin-4D
    Alias: CD100, SEMAJ, coll-4, C9orf164, FLJ33485, FLJ34282, FLJ39737, FLJ46484, M-sema-G, MGC169138, MGC169141, SEMA4D
    Clone: A8
    Predicted Species: Human
    Application: FC, IP, WB
    Format: Purified IgG - liquid
    Size: 0.2mg
    Price:
    $440.00
  5. FYN Antibody (OASA00727)
    FYN Antibody (OASA00727)
    Catalog #: OASA00727
    Protein Name: Tyrosine-protein kinase Fyn
    Alias: SLK, SYN, MGC45350, FYN
    Clone: FYN-01
    Predicted Species: Human
    Application: IHC-AFF, IP, WB
    Format: Purified IgG - liquid
    Size: 0.1mg
    Price:
    $315.00
  6. C-ABL Antibody (OASA00409)
    C-ABL Antibody (OASA00409)
    Catalog #: OASA00409
    Protein Name: Tyrosine-protein kinase ABL1
    Alias: ABL, JTK7, p150, c-ABL, v-abl, bcr/abl, ABL1
    Clone: 8E9
    Application: WB, IF, IP
    Format: Purified IgG - liquid
    Size: 0.1mg
    Price:
    $440.00
  7. Mouse peripheral blood lymphocytes
    Itgb1 Antibody (OASA00074)
    Catalog #: OASA00074
    Protein Name: Integrin beta-1
    Alias: CD29, Fnrb, gpIIa, AA409975, AA960159, 4633401G24Rik, Itgb1
    Clone: HM beta 1-1
    Predicted Species: Mouse
    Application: FC, IP
    Format: Purified IgG - liquid
    Size: 0.25mg
    Price:
    $365.00
  8. Human HepG2
    NRP1 Antibody - N-terminal region (ARP59101_P050)
    Catalog #: ARP59101_P050
    Protein Name: Neuropilin-1
    Alias: BDCA4, CD304, DKFZp686A03134, DKFZp781F1414, NP1, NRP, VEGF165R
    Tested Species: Human
    Predicted Species: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  9. Human Brain
    GNAI3 Antibody - N-terminal region (ARP58905_P050)
    Catalog #: ARP58905_P050
    Protein Name: Guanine nucleotide-binding protein G(k) subunit alpha
    Alias: 87U6, FLJ26559
    Tested Species: Human
    Predicted Species: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00

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