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Axon Guidance

Axon guidance refers to the process by which growing neural axons follow specific, predictable paths to reach their target locations. The tip of the growing axon is known as the growth cone and it is this part of the axon that senses guidance cues (also known as guidance factors) in the surrounding environment. The growth cone receptors respond to the various fixed and diffusible guidance cues and their gradients and respond accordingly. The response is in the form of directional changes in axon growth mediated by cytoskeletal changes. A broad array of signals can function as guidance cues, some of the most well-studied being Netrins, Ephrins and Semaphorins. Each guidance factor serves to attract or repel growth cones during neural development, although different cues can have diverse effects on distinct growth cones. It is the collective influence of the various cues that helps guide axons to their appropriate targets during development. The effects of guidance cues on axon growth can readily be studied in vitro with an array of commercially available factors. Elucidation of the processes that promote and inhibit axon growth during development may provide critical insights into neuroregenerative processes that could benefit patients with spinal cord injuries and other diseases of the nervous system[1].

1. Harel NY and Strittmatter SM. 2006. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci. Aug;7(8):603-16. See Related Product List Below Pathway Image

Axon Guidance pathway image by Aviva System Biology

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    NFATC4 antibody - N-terminal region (ARP38493_P050) in Human 721_B using Western Blot

    NFATC4 antibody - N-terminal region (ARP38493_P050)

    Protein Name:Nuclear factor of activated T-cells, cytoplasmic 4
    Catalog #:ARP38493_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
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    GNAI3 antibody - N-terminal region (ARP58905_P050) in Human Brain using Western Blot

    GNAI3 antibody - N-terminal region (ARP58905_P050)

    Protein Name:Guanine nucleotide-binding protein G(k) subunit alpha
    Catalog #:ARP58905_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    NFATC1 antibody - N-terminal region (P100981_P050) in Human Stomach using Western Blot

    NFATC1 antibody - N-terminal region (P100981_P050)

    Protein Name:Nuclear factor of activated T-cells, cytoplasmic 1
    Catalog #:P100981_P050
    Type: pAb
    Reacts with: Dog, Guinea Pig, Human, Mouse
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $319.00
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    JUN antibody - middle region (ARP30926_P050) in Human Fetal heart using Western Blot

    JUN antibody - middle region (ARP30926_P050)

    Protein Name:Transcription factor AP-1
    Catalog #:ARP30926_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    NRP1 antibody - N-terminal region (ARP59101_P050) in Human HepG2 using Western Blot

    NRP1 antibody - N-terminal region (ARP59101_P050)

    Protein Name:Neuropilin-1
    Catalog #:ARP59101_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    HRAS Antibody (OASA02910)

    HRAS Antibody (OASA02910)

    Protein Name:GTPase HRas
    Catalog #:OASA02910
    Type: mAb
    Reacts with: Human, Mouse, Rat
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $280.00
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    NFATC3 antibody - N-terminal region (P100975_P050) in Human HeLa using Western Blot

    NFATC3 antibody - N-terminal region (P100975_P050)

    Protein Name:Nuclear factor of activated T-cells c3 isoform IB-Xa EMBL ACG55625.1
    Catalog #:P100975_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Rat
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $319.00

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