Angiogenesis, the physiological process through which new blood vessels form from pre-existing vessels, play an essential role in supplying nutrients, oxygen and immune cells to the new vascular network. Angiogenesis is critical in the development of cancer, since the proliferation and metastatic spread of cancer cells is aided by new growth in the vascular network. Angiogenesis is regulated by both activator and inhibitor molecules, where angiogenic activators have been found to play an important part in the growth and spread of tumors.