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Epigenetics

Epigenetics is the study of gene expression changes that result from processes that do not involve alteration of the DNA sequence. During embryogenesis, various epigenetic mechanisms play important roles in governing proper development, including chromatin remodeling and DNA methylation. Given that primary DNA sequences are not altered in a developing embryo, it is the epigenetic modifications that underlie the spatial and temporal control of gene expression. Hyper- and hypo-methylation of DNA can result in reduced and increased transcription of specific genes, respectively. Aberrant methylation patterns have been linked to the development and progression of a variety of cancers. Genomic imprinting is another epigenetic process that has been associated with human diseases, including Angelman Syndrome. Other epigenetic processes include histone acetylation and deacetylation, X chromosome inactivation, and heterochromatin regulation. While it is known that epigenetic changes can be maintained during cell division, evidence is mounting to support the notion that epigenetic marks can be transmitted from one generation to the next. Environmental factors such as stress and diet can have epigenetic consequences and these consequences may be passed on to offspring[1].

1. Waterland RA and Jirtle RL. 2003. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. Aug; 23(15):5293-300.

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    HBO1/MYST2 Antibody (Center) (OAAB01107) in Jurkat using Western Blot

    MYST2 Antibody - middle region (OAAB01107)

    Protein Name:Histone acetyltransferase KAT7
    Catalog #:OAAB01107
    Type: pAb
    Reacts with: Human, Mouse, Rat
    Application: WB, IHC, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    MEN1 Antibody (OAAB04430) in Ramos using Western Blot

    MEN1 Antibody (OAAB04430)

    Protein Name:
    Catalog #:OAAB04430
    Type: pAb
    Reacts with: Human
    Application: WB, IHC, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    SMYD2 Antibody - middle region (ARP81568_P050) in Human Mesenchymoma Tumor using Western Blot

    SMYD2 Antibody - middle region (ARP81568_P050)

    Protein Name:N-lysine methyltransferase SMYD2
    Catalog #:ARP81568_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    SPI1 Antibody (OAEB01703) in Daudicells using Western Blot

    SPI1 Antibody (OAEB01703)

    Protein Name:Transcription factor PU.1
    Catalog #:OAEB01703
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    SETD6 antibody - C-terminal region (OAAB02263) in WiDr using Western Blot

    SETD6 Antibody - C-terminal region (OAAB02263)

    Protein Name:N-lysine methyltransferase SETD6
    Catalog #:OAAB02263
    Type: pAb
    Reacts with: Human
    Application: WB, IHC
    Product Size: 400ul
    Price (USD): $390.00
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    IL1B Antibody (OASA03000)

    IL1B Antibody (OASA03000)

    Protein Name:Interleukin-1 beta
    Catalog #:OASA03000
    Type: mAb
    Reacts with: Human
    Application: ELISA
    Product Size: 0.2mg
    Price (USD): $470.00
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    MIZF antibody - middle region (ARP39196_P050) in Transfected 293T using Western Blot

    MIZF Antibody - middle region (ARP39196_P050)

    Protein Name:Histone H4 transcription factor
    Catalog #:ARP39196_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    Goat Anti-ERK1 / MAPK3 Antibody (OAEB01948) in 293Tcells using Western Blot

    Goat Anti-ERK1 / MAPK3 Antibody (OAEB01948)

    Protein Name:Mitogen-activated protein kinase 3
    Catalog #:OAEB01948
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    COMT Antibody (OAEB02030) in human testiscells using Western Blot

    COMT Antibody (OAEB02030)

    Protein Name:Catechol O-methyltransferase
    Catalog #:OAEB02030
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB, ELISA
    Product Size: 100 ug
    Price (USD): $349.00
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    Goat Anti-Sirtuin 1 / SIRT1 (aa577-590) Antibody (OAEB01045) in Jurkatcells using Western Blot

    Goat Anti-Sirtuin 1 / SIRT1 (aa577-590) Antibody (OAEB01045)

    Protein Name:NAD-dependent protein deacetylase sirtuin-1
    Catalog #:OAEB01045
    Type: pAb
    Reacts with: Guinea Pig, Human, Mouse, Pig, Rat
    Application: IHC, WB
    Product Size: 100 ug
    Price (USD): $349.00
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    RNF8 Antibody (OAAB06421) in Jurkat using Western Blot

    RNF8 Antibody (OAAB06421)

    Protein Name:E3 ubiquitin-protein ligase RNF8
    Catalog #:OAAB06421
    Type: pAb
    Reacts with: Human
    Application: WB, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    NCAPH antibody - N-terminal region (ARP46226_P050) in Human HepG2 using Western Blot

    NCAPH Antibody - N-terminal region (ARP46226_P050)

    Protein Name:Condensin complex subunit 2
    Catalog #:ARP46226_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00

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