Epigenetics

Epigenetics is the study of gene expression changes that result from processes that do not involve alteration of the DNA sequence. During embryogenesis, various epigenetic mechanisms play important roles in governing proper development, including chromatin remodeling and DNA methylation. Given that primary DNA sequences are not altered in a developing embryo, it is the epigenetic modifications that underlie the spatial and temporal control of gene expression. Hyper- and hypo-methylation of DNA can result in reduced and increased transcription of specific genes, respectively. Aberrant methylation patterns have been linked to the development and progression of a variety of cancers. Genomic imprinting is another epigenetic process that has been associated with human diseases, including Angelman Syndrome. Other epigenetic processes include histone acetylation and deacetylation, X chromosome inactivation, and heterochromatin regulation. While it is known that epigenetic changes can be maintained during cell division, evidence is mounting to support the notion that epigenetic marks can be transmitted from one generation to the next. Environmental factors such as stress and diet can have epigenetic consequences and these consequences may be passed on to offspring[1].

1. Waterland RA and Jirtle RL. 2003. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. Aug; 23(15):5293-300.

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  1. Mouse Small Intestine
    APOBEC2 Antibody - middle region (ARP90843_P050)
    Catalog #: ARP90843_P050
    Protein Name: C->U-editing enzyme APOBEC-2
    Alias: Arp1
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  2. Human 786-0 Whole Cell
    MTA1 Antibody - middle region (ARP97962_P050)
    Catalog #: ARP97962_P050
    Protein Name: metastasis-associated protein MTA1
    Predicted Species: Human
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  3. Mouse Spleen
    GFI1B Antibody - C-terminal region (ARP90462_P050)
    Catalog #: ARP90462_P050
    Protein Name: zinc finger protein Gfi-1b
    Alias: Gfi-1B
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  4. Mouse Brain
    UPF1 Antibody - C-terminal region (ARP89425_P050)
    Catalog #: ARP89425_P050
    Protein Name: regulator of nonsense transcripts 1
    Alias: NORF1, Rent1, Upflp, PNORF-1, B430202H16Rik
    Tested Species: Mouse
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  5. Mouse Heart
    EZH2 Antibody - middle region (ARP88917_P050)
    Catalog #: ARP88917_P050
    Protein Name: histone-lysine N-methyltransferase EZH2
    Alias: KMT6, Enx-1, Enx1h, mKIAA4065
    Tested Species: Mouse
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  6. Mouse Testis
    FBLL1 Antibody - C-terminal region (ARP96482_P050)
    Catalog #: ARP96482_P050
    Protein Name: rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1
    Alias: AI595406
    Tested Species: Mouse
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  7. Rat Liver
    TOMT Antibody - middle region (ARP95252_P050)
    Catalog #: ARP95252_P050
    Protein Name: transmembrane O-methyltransferase
    Alias: Comt2, F930017I19Rik
    Tested Species: Rat
    Predicted Species: Rat
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  8. Human PANC1 Whole Cell
    SAP18 Antibody - C-terminal region (ARP97817_P050)
    Catalog #: ARP97817_P050
    Protein Name: histone deacetylase complex subunit SAP18
    Alias: SAP18P, 2HOR0202
    Tested Species: Human
    Predicted Species: Human
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  9. Human PC-3 Whole Cell
    COQ3 Antibody - middle region (ARP82673_P050)
    Catalog #: ARP82673_P050
    Protein Name: ubiquinone biosynthesis O-methyltransferase, mitochondrial
    Alias: DHHBMT, bA9819.1, DHHBMTASE, UG0215E05
    Tested Species: Human
    Predicted Species: Human
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
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