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Epigenetics

Epigenetics is the study of gene expression changes that result from processes that do not involve alteration of the DNA sequence. During embryogenesis, various epigenetic mechanisms play important roles in governing proper development, including chromatin remodeling and DNA methylation. Given that primary DNA sequences are not altered in a developing embryo, it is the epigenetic modifications that underlie the spatial and temporal control of gene expression. Hyper- and hypo-methylation of DNA can result in reduced and increased transcription of specific genes, respectively. Aberrant methylation patterns have been linked to the development and progression of a variety of cancers. Genomic imprinting is another epigenetic process that has been associated with human diseases, including Angelman Syndrome. Other epigenetic processes include histone acetylation and deacetylation, X chromosome inactivation, and heterochromatin regulation. While it is known that epigenetic changes can be maintained during cell division, evidence is mounting to support the notion that epigenetic marks can be transmitted from one generation to the next. Environmental factors such as stress and diet can have epigenetic consequences and these consequences may be passed on to offspring[1].

1. Waterland RA and Jirtle RL. 2003. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. Aug; 23(15):5293-300.

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    COMT antibody - N-terminal region (OAEB02203) in human testiscells using Western Blot

    COMT Antibody - N-terminal region (OAEB02203)

    Protein Name:Catechol O-methyltransferase
    Catalog #:OAEB02203
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Rabbit
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    BHMT2 Antibody - C-terminal region (ARP85229_P050) in Human THP-1 Whole Cell using Western Blot

    BHMT2 Antibody - C-terminal region (ARP85229_P050)

    Protein Name:S-methylmethionine--homocysteine S-methyltransferase BHMT2
    Catalog #:ARP85229_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    SETD8 antibody - center region (OAAB03564) in 293 using Western Blot

    SETD8 Antibody - middle region (OAAB03564)

    Protein Name:N-lysine methyltransferase SETD8
    Catalog #:OAAB03564
    Type: pAb
    Reacts with: Cow, Human
    Application: WB, IHC, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    MTA2 antibody - middle region (ARP35743_P050) in Human 721_B using Western Blot

    MTA2 Antibody - middle region (ARP35743_P050)

    Protein Name:Metastasis-associated protein MTA2
    Catalog #:ARP35743_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    Goat anti-HCFC1 Antibody (OAEB00003)

    Goat anti-HCFC1 Antibody (OAEB00003)

    Protein Name:Host cell factor 1
    Catalog #:OAEB00003
    Type: pAb
    Reacts with:
    Application: ELISA
    Product Size: 0.1mg
    Price (USD): $190.00
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    Goat Anti-APBB1 / FE65 Antibody (OAEB01135) in NIH/3T3cells using Western Blot

    Goat Anti-APBB1 / FE65 Antibody (OAEB01135)

    Protein Name:Amyloid beta A4 precursor protein-binding family B member 1
    Catalog #:OAEB01135
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    DIMT1L Antibody - middle region (ARP79689_P050) in Human A549 whole Cell using Western Blot

    DIMT1 Antibody - middle region (ARP79689_P050)

    Protein Name:probable dimethyladenosine transferase
    Catalog #:ARP79689_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    CSRP2BP antibody - center region (OAAB05461) in Y79, A2058, A375, MDA-MB231 using Western Blot

    CSRP2BP Antibody - middle region (OAAB05461)

    Protein Name:Cysteine-rich protein 2-binding protein
    Catalog #:OAAB05461
    Type: pAb
    Reacts with: Human, Mouse
    Application: WB, IHC, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    SALL1 Antibody (OAEB00032)

    SALL1 Antibody (OAEB00032)

    Protein Name:Sal-like protein 1
    Catalog #:OAEB00032
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: ELISA
    Product Size: 100 ug
    Price (USD): $229.00
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    SALL1 Antibody (OAEB00353)

    SALL1 Antibody (OAEB00353)

    Protein Name:Sal-like protein 1
    Catalog #:OAEB00353
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: ELISA
    Product Size: 100 ug
    Price (USD): $229.00
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    BHMT Antibody (OAEB02378) in Rat Livercells using Western Blot

    BHMT Antibody (OAEB02378)

    Protein Name:Betaine--homocysteine S-methyltransferase 1
    Catalog #:OAEB02378
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    ASH2L Antibody (ARP74398_P050) in Human HepG2 Whole Cell using Western Blot

    ASH2L Antibody - middle region (ARP74398_P050)

    Protein Name:
    Catalog #:ARP74398_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    NARF antibody - middle region (ARP54491_P050) in Human Liver using Western Blot

    NARF Antibody - middle region (ARP54491_P050)

    Protein Name:cDNA FLJ32404 fis, clone SKMUS2000380, highly similar to Homo sapiens nuclear prelamin A recognition factor (NARF), transcript variant 1, mRNA EMBL BAG51834.1
    Catalog #:ARP54491_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    KDM4A Antibody (ARP75275_P050) in Human 293T Whole Cell using Western Blot

    KDM4A Antibody - C-terminal region (ARP75275_P050)

    Protein Name:
    Catalog #:ARP75275_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    PRMT6 Antibody - N-terminal region (ARP88256_P050) in Human A549 Whole Cell using Western Blot

    PRMT6 Antibody - N-terminal region (ARP88256_P050)

    Protein Name:Protein arginine N-methyltransferase 6
    Catalog #:ARP88256_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    POLE3 Antibody (N-term) (OAAB04304) in K562 using Western Blot

    POLE3 Antibody - N-terminal region (OAAB04304)

    Protein Name:DNA polymerase epsilon subunit 3
    Catalog #:OAAB04304
    Type: pAb
    Reacts with: Human
    Application: WB, FC, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    Gsk3b Antibody (OASA07320)

    Gsk3b Antibody (OASA07320)

    Protein Name:Glycogen synthase kinase-3 beta
    Catalog #:OASA07320
    Type: pAb
    Reacts with: Rat
    Application: WB
    Product Size: 0.1 ml
    Price (USD): $770.00
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    POR Antibody (OAEB01434) in Rat Livercells using Western Blot

    POR Antibody (OAEB01434)

    Protein Name:NADPH--cytochrome P450 reductase PIRNR PIRNR000208
    Catalog #:OAEB01434
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    TADA2L antibody - N-terminal region (ARP38044_P050) in Human Jurkat using Western Blot

    TADA2L Antibody - N-terminal region (ARP38044_P050)

    Protein Name:Transcriptional adapter 2-alpha
    Catalog #:ARP38044_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    RNF8 Antibody (OAAB06421) in Jurkat using Western Blot

    RNF8 Antibody (OAAB06421)

    Protein Name:E3 ubiquitin-protein ligase RNF8
    Catalog #:OAAB06421
    Type: pAb
    Reacts with: Human
    Application: WB, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    SRCAP Antibody (OAEB00810)

    SRCAP Antibody (OAEB00810)

    Protein Name:Helicase SRCAP
    Catalog #:OAEB00810
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: ELISA
    Product Size: 100 ug
    Price (USD): $349.00

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