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Epigenetics

Epigenetics is the study of gene expression changes that result from processes that do not involve alteration of the DNA sequence. During embryogenesis, various epigenetic mechanisms play important roles in governing proper development, including chromatin remodeling and DNA methylation. Given that primary DNA sequences are not altered in a developing embryo, it is the epigenetic modifications that underlie the spatial and temporal control of gene expression. Hyper- and hypo-methylation of DNA can result in reduced and increased transcription of specific genes, respectively. Aberrant methylation patterns have been linked to the development and progression of a variety of cancers. Genomic imprinting is another epigenetic process that has been associated with human diseases, including Angelman Syndrome. Other epigenetic processes include histone acetylation and deacetylation, X chromosome inactivation, and heterochromatin regulation. While it is known that epigenetic changes can be maintained during cell division, evidence is mounting to support the notion that epigenetic marks can be transmitted from one generation to the next. Environmental factors such as stress and diet can have epigenetic consequences and these consequences may be passed on to offspring[1].

1. Waterland RA and Jirtle RL. 2003. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. Aug; 23(15):5293-300.

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    TRIM28 antibody - N-terminal region (ARP32677_P050) in Human HeLa using Western Blot

    TRIM28 Antibody - N-terminal region (ARP32677_P050)

    Protein Name:Transcription intermediary factor 1-beta
    Catalog #:ARP32677_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00
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    GATA2 antibody - center region (OAAB03861) in GATA2 using Western Blot

    GATA2 Antibody - middle region (OAAB03861)

    Protein Name:Endothelial transcription factor GATA-2
    Catalog #:OAAB03861
    Type: pAb
    Reacts with: Human, Mouse, Rat
    Application: WB, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    ATXN7L3 Antibody - middle region (ARP67018_P050) in Human 721_B using Western Blot

    ATXN7L3 Antibody - middle region (ARP67018_P050)

    Protein Name:Ataxin-7-like protein 3
    Catalog #:ARP67018_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    SRCAP Antibody (OAEB00810)

    SRCAP Antibody (OAEB00810)

    Protein Name:Helicase SRCAP
    Catalog #:OAEB00810
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: ELISA
    Product Size: 100 ug
    Price (USD): $349.00
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    WAC antibody - center region (OAAB06134) in HepG2 using Western Blot

    WAC Antibody - middle region (OAAB06134)

    Protein Name:WW domain-containing adapter protein with coiled-coil
    Catalog #:OAAB06134
    Type: pAb
    Reacts with: Human
    Application: WB, FC, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    COQ3 Antibody (ARP48797_P050) in Human MCF7 Whole Cell using Western Blot

    COQ3 Antibody - middle region (ARP48797_P050)

    Protein Name:Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial
    Catalog #:ARP48797_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    Muc1 Antibody (OAMA02431)

    Muc1 Antibody (OAMA02431)

    Protein Name:Mucin-1
    Catalog #:OAMA02431
    Type: mAb
    Reacts with: Human
    Application: ELISA, IHC-F
    Product Size: 1 mg
    Price (USD): $639.00
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    ATF7IP2 Antibody - middle region (ARP86387_P050) in Human HCT116 Whole Cell using Western Blot

    ATF7IP2 Antibody - middle region (ARP86387_P050)

    Protein Name:activating transcription factor 7-interacting protein 2
    Catalog #:ARP86387_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    Sept12 antibody - middle region (ARP52696_P050) in Mouse Liver using Western Blot

    SEPT12 Antibody - middle region (ARP52696_P050)

    Protein Name:Protein Sept12 Ensembl ENSMUSP00000131062
    Catalog #:ARP52696_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00

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Showing 1 - 30 of 1478