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Epigenetics

Epigenetics is the study of gene expression changes that result from processes that do not involve alteration of the DNA sequence. During embryogenesis, various epigenetic mechanisms play important roles in governing proper development, including chromatin remodeling and DNA methylation. Given that primary DNA sequences are not altered in a developing embryo, it is the epigenetic modifications that underlie the spatial and temporal control of gene expression. Hyper- and hypo-methylation of DNA can result in reduced and increased transcription of specific genes, respectively. Aberrant methylation patterns have been linked to the development and progression of a variety of cancers. Genomic imprinting is another epigenetic process that has been associated with human diseases, including Angelman Syndrome. Other epigenetic processes include histone acetylation and deacetylation, X chromosome inactivation, and heterochromatin regulation. While it is known that epigenetic changes can be maintained during cell division, evidence is mounting to support the notion that epigenetic marks can be transmitted from one generation to the next. Environmental factors such as stress and diet can have epigenetic consequences and these consequences may be passed on to offspring[1].

1. Waterland RA and Jirtle RL. 2003. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. Aug; 23(15):5293-300.

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    SPIT2 Antibody (ARP49614_P050) in Human MCF7 Whole Cell using Western Blot

    SPINT2 Antibody - middle region (ARP49614_P050)

    Protein Name:kunitz-type protease inhibitor 2
    Catalog #:ARP49614_P050
    Type: pAb
    Reacts with: Cow, Horse, Human, Pig
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    Goat anti-CREBBP Antibody (OAEB00713)

    Goat anti-CREBBP Antibody (OAEB00713)

    Protein Name:CREB-binding protein
    Catalog #:OAEB00713
    Type: pAb
    Reacts with:
    Application: ELISA
    Product Size: 0.1mg
    Price (USD): $190.00
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    OGT Antibody (OAEB02007) in Rat Pancreascells using Western Blot

    OGT Antibody (OAEB02007)

    Protein Name:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
    Catalog #:OAEB02007
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    JHDM1D Antibody (OAAB02533) in 293 using Western Blot

    JHDM1D Antibody - middle region (OAAB02533)

    Protein Name:Lysine-specific demethylase 7
    Catalog #:OAAB02533
    Type: pAb
    Reacts with: Human
    Application: WB, IHC, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    Zbtb7a antibody - C-terminal region (ARP39212_P050) in Mouse Pancreas using Western Blot

    Zbtb7a Antibody - C-terminal region (ARP39212_P050)

    Protein Name:Zinc finger and BTB domain-containing protein 7A
    Catalog #:ARP39212_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    PRKCA Antibody (OASA03762)

    PRKCA Antibody (OASA03762)

    Protein Name:Protein kinase C alpha type
    Catalog #:OASA03762
    Type: mAb
    Reacts with:
    Application: IHC-AFF, WB
    Product Size: 2 ml
    Price (USD): $509.00
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    Goat Anti-MRG15 / MORF4L1 Antibody (OAEB00913) in Mouse Livercells using Western Blot

    Goat Anti-MRG15 / MORF4L1 Antibody (OAEB00913)

    Protein Name:MORF4L1 protein EMBL AAI21094.1
    Catalog #:OAEB00913
    Type: pAb
    Reacts with: Cow, Human, Mouse, Pig, Zebrafish
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    Goat Anti-TAK1 / MAP3K7 Antibody (OAEB01117) in HEK293cells using Western Blot

    Goat Anti-TAK1 / MAP3K7 Antibody (OAEB01117)

    Protein Name:Mitogen-activated protein kinase kinase kinase 7 EMBL AAV38460.1
    Catalog #:OAEB01117
    Type: pAb
    Reacts with: Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    COQ3 Antibody - middle region (ARP82673_P050) in Human PC-3 Whole Cell using Western Blot

    COQ3 Antibody - middle region (ARP82673_P050)

    Protein Name:ubiquinone biosynthesis O-methyltransferase, mitochondrial
    Catalog #:ARP82673_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    PGM2 antibody - C-terminal region (ARP63674_P050) in Human THP-1 using Western Blot

    PGM2 Antibody - C-terminal region (ARP63674_P050)

    Protein Name:Phosphoglucomutase-2
    Catalog #:ARP63674_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    APOBEC2 antibody - middle region (ARP40682_P050) in COLO205 using Western Blot

    APOBEC2 Antibody - middle region (ARP40682_P050)

    Protein Name:Probable C->U-editing enzyme APOBEC-2
    Catalog #:ARP40682_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    KCNIP2 antibody - C-terminal region (ARP35489_P050) in Human 293T using Western Blot

    KCNIP2 Antibody - C-terminal region (ARP35489_P050)

    Protein Name:Kv channel-interacting protein 2
    Catalog #:ARP35489_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    HIST1H1D Antibody (ARP54756_P050) in Human Liver Tumor using Western Blot

    HIST1H1D Antibody - N-terminal region (ARP54756_P050)

    Protein Name:Histone H1.3
    Catalog #:ARP54756_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    RNF8 Antibody (OAEB02078) in Human Lungcells using Western Blot

    RNF8 Antibody (OAEB02078)

    Protein Name:E3 ubiquitin-protein ligase RNF8
    Catalog #:OAEB02078
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    Rdx antibody - C-terminal region (ARP56520_P050) in Mouse Small Intestine using Western Blot

    Rdx Antibody - C-terminal region (ARP56520_P050)

    Protein Name:Radixin
    Catalog #:ARP56520_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    OGT antibody - C-terminal region (OAAB03753) in mouse bladder using Western Blot

    OGT Antibody - C-terminal region (OAAB03753)

    Protein Name:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
    Catalog #:OAAB03753
    Type: pAb
    Reacts with: Human, Mouse, Pig, Rabbit, Rat
    Application: WB, IHC, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    Pskh1 antibody - C-terminal region (ARP56720_P050) in Mouse Heart using Western Blot

    Pskh1 Antibody - C-terminal region (ARP56720_P050)

    Protein Name:Serine/threonine-protein kinase H1
    Catalog #:ARP56720_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    PATZ1 antibody - N-terminal region (ARP32520_P050) in Human OVCAR-3 using Western Blot

    PATZ1 Antibody - N-terminal region (ARP32520_P050)

    Protein Name:POZ-, AT hook-, and zinc finger-containing protein 1
    Catalog #:ARP32520_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    CDK9 Antibody (OASA07138)

    CDK9 Antibody (OASA07138)

    Protein Name:Cyclin-dependent kinase 9
    Catalog #:OASA07138
    Type: pAb
    Reacts with: Human
    Application: IHC-AFF, ELISA, IP, IHC-FFPE, WB
    Product Size: 0.1 ml
    Price (USD): $829.00
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    ALX3 Antibody (ARP36818_P050) in Human Thymus Tumor using Western Blot

    ALX3 Antibody - C-terminal region (ARP36818_P050)

    Protein Name:Homeobox protein aristaless-like 3
    Catalog #:ARP36818_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    ZCCHC4 Antibody - middle region (ARP80484_P050) in Human Neurofibroma Tumor using Western Blot

    ZCCHC4 Antibody - middle region (ARP80484_P050)

    Protein Name:zinc finger CCHC domain-containing protein 4
    Catalog #:ARP80484_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00

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