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Epigenetics

Epigenetics is the study of gene expression changes that result from processes that do not involve alteration of the DNA sequence. During embryogenesis, various epigenetic mechanisms play important roles in governing proper development, including chromatin remodeling and DNA methylation. Given that primary DNA sequences are not altered in a developing embryo, it is the epigenetic modifications that underlie the spatial and temporal control of gene expression. Hyper- and hypo-methylation of DNA can result in reduced and increased transcription of specific genes, respectively. Aberrant methylation patterns have been linked to the development and progression of a variety of cancers. Genomic imprinting is another epigenetic process that has been associated with human diseases, including Angelman Syndrome. Other epigenetic processes include histone acetylation and deacetylation, X chromosome inactivation, and heterochromatin regulation. While it is known that epigenetic changes can be maintained during cell division, evidence is mounting to support the notion that epigenetic marks can be transmitted from one generation to the next. Environmental factors such as stress and diet can have epigenetic consequences and these consequences may be passed on to offspring[1].

1. Waterland RA and Jirtle RL. 2003. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. Aug; 23(15):5293-300.

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    SNCA Antibody (OASA06014)

    SNCA Antibody (OASA06014)

    Protein Name:Alpha-synuclein
    Catalog #:OASA06014
    Type: pAb
    Reacts with: Human
    Application: IHC-FFPE
    Product Size: 0.1 ml
    Price (USD): $410.00
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    SPI1 Antibody (OAEB01703) in Daudicells using Western Blot

    SPI1 Antibody (OAEB01703)

    Protein Name:Transcription factor PU.1
    Catalog #:OAEB01703
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ug
    Price (USD): $299.00
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    METTL5 Antibody - middle region (ARP83276_P050) in Human Ovary Tumor using Western Blot

    METTL5 Antibody - middle region (ARP83276_P050)

    Protein Name:methyltransferase-like protein 5
    Catalog #:ARP83276_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
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    MEN1 Antibody (OAAB04430) in Ramos using Western Blot

    MEN1 Antibody (OAAB04430)

    Protein Name:
    Catalog #:OAAB04430
    Type: pAb
    Reacts with: Human
    Application: WB, IHC
    Product Size: 400ul
    Price (USD): $329.00
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    ZCCHC11 Antibody (OASA06308)

    ZCCHC11 Antibody (OASA06308)

    Protein Name:Terminal uridylyltransferase 4
    Catalog #:OASA06308
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $575.00
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    ARID3B antibody - C-terminal region (ARP38798_P050) in Human HepG2 using Western Blot

    ARID3B Antibody - C-terminal region (ARP38798_P050)

    Protein Name:AT-rich interactive domain-containing protein 3B
    Catalog #:ARP38798_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
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    Tbce antibody - N-terminal region (ARP61755_P050) in Mouse Liver using Western Blot

    Tbce Antibody - N-terminal region (ARP61755_P050)

    Protein Name:Tubulin-specific chaperone E
    Catalog #:ARP61755_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
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    Zhx1 antibody - C-terminal region (ARP32853_P050) in Mouse Heart using Western Blot

    Zhx1 Antibody - C-terminal region (ARP32853_P050)

    Protein Name:Zinc fingers and homeoboxes protein 1
    Catalog #:ARP32853_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
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    COMT Antibody (OAEB02030) in human testiscells using Western Blot

    COMT Antibody (OAEB02030)

    Protein Name:Catechol O-methyltransferase
    Catalog #:OAEB02030
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ug
    Price (USD): $299.00

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