Cell Markers
The ability to identify and characterize molecules or proteins expressed within cells is vital for biological and medical research. These markers serve as distinctive signatures, assisting researchers in classifying diverse cell types, functions, and states.
In medical research and clinical settings, cell markers assess cellular responses to treatments, aiding in the evaluation of therapeutic interventions' effectiveness. The identification of novel cell markers contributes to biomarker discovery, holding significance in disease diagnosis, prognosis, and monitoring. These biomarkers may also become potential targets for therapeutic interventions, underscoring the critical role of cell marker research in advancing understanding and treatment in the field.
With a catalog boasting over 15,000 protein targets, trial sizes for exploring emerging projects, and advanced validation methods, Aviva is dedicated to supporting researchers as they pave the way for new discoveries and breakthroughs in Cell Markers research.

Nocodazole treatment decreases expression of pluripotency markers Nanog and Oct4 in human embryonic stem cells
https://pubmed.ncbi.nlm.nih.gov/21559451/
Product: ARP30891_P050
Target: NANOG
Application: WB
This study investigates the effects of nocodazole-induced cell-cycle arrest on pluripotency in human embryonic stem cells (hESCs). It demonstrates that nocodazole reversibly blocks the cell cycle at the G2/M phase but leads to an irreversible loss of key pluripotency markers Nanog and Oct4, alongside increased apoptosis and p53 upregulation, with no restoration of pluripotency markers post-treatment.