Axon Guidance

Axon guidance refers to the process by which growing neural axons follow specific, predictable paths to reach their target locations. The tip of the growing axon is known as the growth cone and it is this part of the axon that senses guidance cues (also known as guidance factors) in the surrounding environment. The growth cone receptors respond to the various fixed and diffusible guidance cues and their gradients and respond accordingly. The response is in the form of directional changes in axon growth mediated by cytoskeletal changes. A broad array of signals can function as guidance cues, some of the most well-studied being Netrins, Ephrins and Semaphorins. Each guidance factor serves to attract or repel growth cones during neural development, although different cues can have diverse effects on distinct growth cones. It is the collective influence of the various cues that helps guide axons to their appropriate targets during development. The effects of guidance cues on axon growth can readily be studied in vitro with an array of commercially available factors. Elucidation of the processes that promote and inhibit axon growth during development may provide critical insights into neuroregenerative processes that could benefit patients with spinal cord injuries and other diseases of the nervous system[1].

1. Harel NY and Strittmatter SM. 2006. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci. Aug;7(8):603-16. See Related Product List Below Pathway Image

Axon Guidance pathway image by Aviva System Biology

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  1. Mouse Heart
    Ppp3cb Antibody - C-terminal region (ARP57516_P050)
    Catalog #: ARP57516_P050
    Protein Name: Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
    Alias: 1110063J16Rik, Calnb, CnAbeta, Cnab
    Tested Species: Mouse
    Predicted Species: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  2. Mouse Brain
    Srgap1 Antibody - middle region (ARP57446_P050)
    Catalog #: ARP57446_P050
    Protein Name: SLIT-ROBO Rho GTPase-activating protein 1
    Alias: Arhgap13, 4930572H05Rik, Srgap1
    Tested Species: Mouse
    Predicted Species: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  3. Pak3 Antibody (OASA08697)
    Pak3 Antibody (OASA08697)
    Catalog #: OASA08697
    Protein Name: Serine/threonine-protein kinase PAK 3
    Alias: beta-PAK, Pak3
    Predicted Species: Rat
    Application: WB
    Format: Purified IgG - liquid
    Size: 0.1ml
    Price:
    $510.00
  4. MAPK1 Antibody - C-terminal region (OASA08679)
    MAPK1 Antibody - C-terminal region (OASA08679)
    Catalog #: OASA08679
    Protein Name: Mitogen-activated protein kinase 1
    Alias: Erk2, Mapk1
    Application: WB
    Format: Purified IgG - liquid
    Size: 0.1ml
    Price:
    $650.00
  5. PAK2 Antibody - C-terminal region (OASA08545)
    PAK2 Antibody - C-terminal region (OASA08545)
    Catalog #: OASA08545
    Protein Name: Serine/threonine-protein kinase PAK 2
    Alias: PAK65, PAKgamma, PAK2
    Predicted Species: Human
    Application: WB
    Format: Purified IgG - liquid
    Size: 0.1 mg
    Price:
    $409.00
  6. Rabbit ANTI Human PAK6 Antibody (OASA08076)
    Rabbit ANTI Human PAK6 Antibody (OASA08076)
    Catalog #: OASA08076
    Protein Name: Serine/threonine-protein kinase PAK 6
    Alias: PAK5, PAK6
    Application: WB
    Format: Purified IgG - liquid
    Size: 0.1mg
    Price:
    $270.00
  7. Rabbit ANTI Human PAK4 Antibody (OASA08074)
    Rabbit ANTI Human PAK4 Antibody (OASA08074)
    Catalog #: OASA08074
    Protein Name: Serine/threonine-protein kinase PAK 4
    Alias: PAK4
    Application: WB
    Format: Purified IgG - liquid
    Size: 0.1mg
    Price:
    $270.00
  8. PTK2 Antibody (OASA07758)
    PTK2 Antibody (OASA07758)
    Catalog #: OASA07758
    Protein Name: Focal adhesion kinase 1
    Alias: FAK, FADK, FAK1, FRNK, pp125FAK, PTK2
    Predicted Species: Human
    Application: IHC-FFPE
    Format: Purified IgG - liquid
    Size: 50 ug
    Price:
    $709.00
  9. EPHA4 Antibody (OASA07724)
    EPHA4 Antibody (OASA07724)
    Catalog #: OASA07724
    Protein Name: Ephrin type-A receptor 4
    Alias: SEK, HEK8, TYRO1, EPHA4
    Predicted Species: Human
    Application: IHC-FFPE
    Format: Purified IgG - liquid
    Size: 50ug
    Price:
    $770.00
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