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Axon Guidance

Axon guidance refers to the process by which growing neural axons follow specific, predictable paths to reach their target locations. The tip of the growing axon is known as the growth cone and it is this part of the axon that senses guidance cues (also known as guidance factors) in the surrounding environment. The growth cone receptors respond to the various fixed and diffusible guidance cues and their gradients and respond accordingly. The response is in the form of directional changes in axon growth mediated by cytoskeletal changes. A broad array of signals can function as guidance cues, some of the most well-studied being Netrins, Ephrins and Semaphorins. Each guidance factor serves to attract or repel growth cones during neural development, although different cues can have diverse effects on distinct growth cones. It is the collective influence of the various cues that helps guide axons to their appropriate targets during development. The effects of guidance cues on axon growth can readily be studied in vitro with an array of commercially available factors. Elucidation of the processes that promote and inhibit axon growth during development may provide critical insights into neuroregenerative processes that could benefit patients with spinal cord injuries and other diseases of the nervous system[1].

1. Harel NY and Strittmatter SM. 2006. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci. Aug;7(8):603-16. See Related Product List Below Pathway Image

Axon Guidance pathway image by Aviva System Biology

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    RGS3 antibody - C-terminal region (AVARP09007_T100) in HepG2 using Western Blot

    RGS3 Antibody - C-terminal region (AVARP09007_T100)

    Protein Name:Regulator of G-protein signaling 3
    Catalog #:AVARP09007_T100
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
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    LRRC4C antibody - N-terminal region (ARP49593_P050) in Human 293T using Western Blot

    LRRC4C Antibody - N-terminal region (ARP49593_P050)

    Protein Name:Leucine-rich repeat-containing protein 4C
    Catalog #:ARP49593_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    UNC5C antibody - C-terminal region (ARP45510_P050) in Human Jurkat using Western Blot

    UNC5C Antibody - C-terminal region (ARP45510_P050)

    Protein Name:Netrin receptor UNC5C
    Catalog #:ARP45510_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    LPHN1 Antibody - C-terminal region (ARP65781_P050) in Human HeLa using Western Blot

    ADGRL1 Antibody - C-terminal region (ARP65781_P050)

    Protein Name:adhesion G protein-coupled receptor L1
    Catalog #:ARP65781_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    PLXNA2 antibody - N-terminal region (ARP49932_P050) in Human HeLa using Western Blot

    PLXNA2 Antibody - N-terminal region (ARP49932_P050)

    Protein Name:Plexin-A2
    Catalog #:ARP49932_P050
    Type: pAb
    Reacts with: Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    JUN antibody - middle region (ARP30926_P050) in Human Fetal heart using Western Blot

    JUN Antibody - middle region (ARP30926_P050)

    Protein Name:Transcription factor AP-1
    Catalog #:ARP30926_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    NFATC2 antibody - N-terminal region (ARP37106_T100) in Mouse SP2/0 using Western Blot

    NFATC2 Antibody - N-terminal region (ARP37106_T100)

    Protein Name:Nuclear factor of activated T-cells, cytoplasmic 2
    Catalog #:ARP37106_T100
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Pig, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $249.00
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    HRAS Antibody (OASA02910)

    HRAS Antibody (OASA02910)

    Protein Name:GTPase HRas
    Catalog #:OASA02910
    Type: mAb
    Reacts with: Human, Mouse, Rat
    Application: ELISA, WB
    Product Size: 0.1 mg
    Price (USD): $309.00
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    FES antibody - N-terminal region (ARP54608_P050) in Human Placenta using Western Blot

    FES Antibody - N-terminal region (ARP54608_P050)

    Protein Name:Tyrosine-protein kinase Fes/Fps
    Catalog #:ARP54608_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    SEMA6D antibody - N-terminal region (ARP49584_P050) in Human 721_B using Western Blot

    SEMA6D Antibody - N-terminal region (ARP49584_P050)

    Protein Name:Semaphorin-6D Ensembl ENSP00000453661 Ensembl ENSP00000348276
    Catalog #:ARP49584_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    EFNA2 antibody - middle region (ARP61345_P050) in Human Placenta using Western Blot

    EFNA2 Antibody - middle region (ARP61345_P050)

    Protein Name:Ephrin-A2
    Catalog #:ARP61345_P050
    Type: pAb
    Reacts with: Cow, Guinea Pig, Human, Mouse, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    RHOD antibody - C-terminal region (ARP42414_P050) in Transfected 293T using Western Blot

    RHOD Antibody - C-terminal region (ARP42414_P050)

    Protein Name:Rho-related GTP-binding protein RhoD
    Catalog #:ARP42414_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
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    Ppp3cb antibody - C-terminal region (ARP57516_P050) in Mouse Heart using Western Blot

    Ppp3cb Antibody - C-terminal region (ARP57516_P050)

    Protein Name:Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
    Catalog #:ARP57516_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    DCC antibody - middle region (ARP46583_P050) in Human ACHN using Western Blot

    DCC Antibody - middle region (ARP46583_P050)

    Protein Name:Netrin receptor DCC
    Catalog #:ARP46583_P050
    Type: pAb
    Reacts with: Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $319.00
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    PPP3R1 antibody - N-terminal region (ARP56124_P050) in Human NCI-H226 using Western Blot

    PPP3R1 Antibody - N-terminal region (ARP56124_P050)

    Protein Name:Calcineurin subunit B type 1
    Catalog #:ARP56124_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00

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