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Axon Guidance

Axon guidance refers to the process by which growing neural axons follow specific, predictable paths to reach their target locations. The tip of the growing axon is known as the growth cone and it is this part of the axon that senses guidance cues (also known as guidance factors) in the surrounding environment. The growth cone receptors respond to the various fixed and diffusible guidance cues and their gradients and respond accordingly. The response is in the form of directional changes in axon growth mediated by cytoskeletal changes. A broad array of signals can function as guidance cues, some of the most well-studied being Netrins, Ephrins and Semaphorins. Each guidance factor serves to attract or repel growth cones during neural development, although different cues can have diverse effects on distinct growth cones. It is the collective influence of the various cues that helps guide axons to their appropriate targets during development. The effects of guidance cues on axon growth can readily be studied in vitro with an array of commercially available factors. Elucidation of the processes that promote and inhibit axon growth during development may provide critical insights into neuroregenerative processes that could benefit patients with spinal cord injuries and other diseases of the nervous system[1].

1. Harel NY and Strittmatter SM. 2006. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci. Aug;7(8):603-16. See Related Product List Below Pathway Image

Axon Guidance pathway image by Aviva System Biology

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    Itgb1 Antibody (OASA00074) in mouse peripheral blood lymphocytes using Flow Cytometry

    Itgb1 Antibody (OASA00074)

    Protein Name:Integrin beta-1
    Catalog #:OASA00074
    Type: mAb
    Reacts with: Mouse
    Application: FC, IP
    Product Size: 0.25mg
    Price (USD): $365.00
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    Mapk3 Antibody (OASA07240)

    Mapk3 Antibody (OASA07240)

    Protein Name:Mitogen-activated protein kinase 3
    Catalog #:OASA07240
    Type: pAb
    Reacts with: Rat
    Application: WB
    Product Size: 0.1 ml
    Price (USD): $750.00
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    SPAM1 Antibody (ARP64265_P050) in Human 786-0 Whole Cell using Western Blot

    SPAM1 Antibody - middle region (ARP64265_P050)

    Protein Name:
    Catalog #:ARP64265_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $319.00
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    Cxcl12 Antibody (OASA06686)

    Cxcl12 Antibody (OASA06686)

    Protein Name:Stromal cell-derived factor 1
    Catalog #:OASA06686
    Type: pAb
    Reacts with: Mouse
    Application: ELISA, WB
    Product Size: 0.1 mg
    Price (USD): $609.00
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    CHP antibody - N-terminal region (ARP52307_P050) in Human 721_B using Western Blot

    CHP Antibody - N-terminal region (ARP52307_P050)

    Protein Name:Calcineurin B homologous protein 1
    Catalog #:ARP52307_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $319.00
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    SEMA3D antibody - middle region (ARP55526_P050) in Human THP-1 using Western Blot

    SEMA3D Antibody - middle region (ARP55526_P050)

    Protein Name:Semaphorin-3D
    Catalog #:ARP55526_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $319.00
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    Srgap1 antibody - middle region (ARP57446_P050) in Mouse Brain using Western Blot

    Srgap1 Antibody - middle region (ARP57446_P050)

    Protein Name:SLIT-ROBO Rho GTPase-activating protein 1
    Catalog #:ARP57446_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    SEMA4B antibody - N-terminal region (ARP49485_P050) in Human Brain using Western Blot

    SEMA4B Antibody - N-terminal region (ARP49485_P050)

    Protein Name:Semaphorin-4B
    Catalog #:ARP49485_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $319.00
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    RHOA antibody - middle region (ARP58521_P050) in 293T using Western Blot

    RHOA Antibody - middle region (ARP58521_P050)

    Protein Name:Transforming protein RhoA
    Catalog #:ARP58521_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    NFATC3 antibody - N-terminal region (P100975_P050) in Human HeLa using Western Blot

    NFATC3 Antibody - N-terminal region (P100975_P050)

    Protein Name:Nuclear factor of activated T-cells c3 isoform IB-Xa EMBL ACG55625.1
    Catalog #:P100975_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Rat
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $319.00
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    EPHA5 antibody - middle region (ARP58460_P050) in Human Brain using Western Blot

    EPHA5 Antibody - middle region (ARP58460_P050)

    Protein Name:Ephrin type-A receptor 5
    Catalog #:ARP58460_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $319.00
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    RAC1 antibody - middle region (ARP57798_P050) in Human HepG2 using Western Blot

    RAC1 Antibody - middle region (ARP57798_P050)

    Protein Name:Ras-related C3 botulinum toxin substrate 1
    Catalog #:ARP57798_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $319.00
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    SLIT3 antibody - N-terminal region (ARP58766_P050) in Jurkat using Western Blot

    SLIT3 Antibody - N-terminal region (ARP58766_P050)

    Protein Name:Slit homolog 3 protein
    Catalog #:ARP58766_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $319.00
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    NTN4 antibody - N-terminal region (ARP49645_P050) in Human MCF7 using Western Blot

    NTN4 Antibody - N-terminal region (ARP49645_P050)

    Protein Name:Netrin-4
    Catalog #:ARP49645_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $319.00
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    UNC5A antibody - middle region (ARP50294_P050) in Human HeLa using Western Blot

    UNC5A Antibody - middle region (ARP50294_P050)

    Protein Name:Netrin receptor UNC5A
    Catalog #:ARP50294_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $319.00
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    SLIT1 antibody - middle region (ARP58765_P050) in Human Stomach using Western Blot

    SLIT1 Antibody - middle region (ARP58765_P050)

    Protein Name:Slit homolog 1 protein
    Catalog #:ARP58765_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $319.00
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    GNAI1 antibody - middle region (ARP54630_P050) in human thryoid using Western Blot

    GNAI1 Antibody - middle region (ARP54630_P050)

    Protein Name:Guanine nucleotide-binding protein G(i) subunit alpha-1
    Catalog #:ARP54630_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep, Yeast, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $319.00
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    SEMA7A Antibody (OASA02604)

    SEMA7A Antibody (OASA02604)

    Protein Name:Semaphorin-7A
    Catalog #:OASA02604
    Type: mAb
    Reacts with: Human
    Application: FC, IP, WB
    Product Size: 0.2mg
    Price (USD): $545.00

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