Exoc4 Antibody (OAED00236)

Catalog No: OAED00236

Size:50 ug

Western blot analysis of rSec8: Lane 1: Lane 2: Brain (rat), (tissue extract); Lane 3: Brain (mouse), (tissue extract); Lane 4: MDBK Cell Lysate.

Immunohistochemistry analysis of human brain, cerebellum tissue stained with rSec8, mAb (14G1) at 5 ug/ml.

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Bovine, Dog, Chicken, Fish, Guinea Pig, Hamster, Monkey, Pig, Rabbit, Sheep
• Product Format: Liquid. PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
• Clonality: Monoclonal
• Clone: 14G1
• Isotype: IgG1
• Host: Mouse
• Application: IP, WB, ICC, IHC (PS)
• Reconstitution and Storage: Store at -20C. Avoid freeze/thaw cycles.
• Immunogen: Recombinant rat rSec8.
• Purification: Protein G affinity purified
• Concentration: 1.0 mg/ml
• Application Info: IP: 12.5 ug/ml
  WB: 1:1000, colorimetric
  Optimal dilutions should be determined by the end user.

Target Info

• Gene Symbol: Exoc4
• Gene Full Name: Exocyst complex component 4
• Alias Symbols: ALR, Sec8, Sec8l1
• NCBI Gene Id: 116654
• Protein Name: Exocyst complex component 4
• Description of Target: rSec6 and rSec8 are rat homologs of the yeast Sec6 and Sec8 proteins that are essential for protein transport between the Golgi apparatus and the plasma membrane. In yeast, Sec8 is part of a 19.5S complex that includes Sec6 and Sec15, that also associate with the ras-like GTP binding protein Sec4. An analogous 17S complex in rat brain was found to contain rSec6 and rSec8, along with eight proteins with a combined molecular weight of 743 kDa. The membrane-associated rSec6/8 complex co-immunoprecipitates with syntaxin, providing evidence that this complex is involved in synaptic vesicle docking and fusion at the presynaptic terminal.
• Uniprot ID: Q62824
• Protein Accession #: NP_446327.1
• Nucleotide Accession #: NM_053875.1
• Molecular Weight: ~110 kDa