Size:100 ul
Special Price $229.00 Regular Price $289.00
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ARP32389_P050
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Conjugation Options

ARP32389_P050-FITC Conjugated

ARP32389_P050-HRP Conjugated

ARP32389_P050-Biotin Conjugated

SIRT3 Antibody - C-terminal region (ARP32389_P050)

Catalog#: ARP32389_P050
Domestic: within 1-2 days delivery | International: 1-2 days
More Information
Tested Species Reactivity Human
Predicted Species Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application IHC, WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-135795 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human SIRT3
Purification Affinity Purified
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 79%; Guinea Pig: 79%; Horse: 86%; Human: 100%; Mouse: 86%; Rabbit: 100%; Rat: 79%
Complete computational species homology data Anti-SIRT3 (ARP32389_P050)
Peptide Sequence Synthetic peptide located within the following region: VGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGP
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-SIRT3 (ARP32389_P050) antibody is Catalog # AAP32389 (Previous Catalog # AAPP03379)
Datasheets/Manuals Printable datasheet for anti-SIRT3 (ARP32389_P050) antibody
Target Reference Onyango,P., et al., (2002) Proc. Natl. Acad. Sci. U.S.A. 15 99(21), 13653-8
Publications

Dong, R. et al. Cells with dendritic cell morphology and immunophenotype, binuclear morphology, and immunosuppressive function in dendritic cell cultures. Cell. Immunol. 272, 1-10 (2011). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat 22087287

Lanza, I. R. et al. Endurance exercise as a countermeasure for aging. Diabetes 57, 2933-42 (2008). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat 18716044

Vidimar, V; Gius, D; Chakravarti, D; Bulun, SE; Wei, JJ; Kim, JJ; Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas. 2, e1601132 (2016). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat 27847869

Gene Symbol SIRT3
Official Gene Full Name Sirtuin 3
Alias Symbols SIR2L3
NCBI Gene Id 23410
Protein Name NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Description of Target The SIRT3 gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT3 encodes a protein that is included in class I of the sirtuin family.
Swissprot Id Q9NTG7
Protein Accession # NP_001017524
Nucleotide Accession # NM_001017524
Protein Size (# AA) 257
Molecular Weight 28kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express SIRT3.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express SIRT3.
Protein Interactions SIRT5; SKP2; UBC; HSPD1; CMYA5; PGAP1; RIF1; NCAPD2; HERC2; TTF2; UQCRH; UGDH; HSP90B1; SNTB1; SBF1; HSPA9; HSPA5; HSPA4; HSPA1L; GRN; ATP5B; ATP5A1; SIRT4; tat; XRCC6; FOXO3; DNM1L; PEX5;
  1. What is the species homology for "SIRT3 Antibody - C-terminal region (ARP32389_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat".

  2. How long will it take to receive "SIRT3 Antibody - C-terminal region (ARP32389_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "SIRT3 Antibody - C-terminal region (ARP32389_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "SIRT3 Antibody - C-terminal region (ARP32389_P050)"?

    This target may also be called "SIR2L3" in publications.

  5. What is the shipping cost for "SIRT3 Antibody - C-terminal region (ARP32389_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "SIRT3 Antibody - C-terminal region (ARP32389_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "SIRT3 Antibody - C-terminal region (ARP32389_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "28kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "SIRT3 Antibody - C-terminal region (ARP32389_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "SIRT3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "SIRT3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "SIRT3"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "SIRT3"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "SIRT3"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "SIRT3"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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