| Product Number |
ARP32389_P050 |
| Product Page |
www.avivasysbio.com/sirt3-antibody-c-terminal-region-arp32389-p050.html |
| Name |
SIRT3 Antibody - C-terminal region (ARP32389_P050) |
| Protein Size (# AA) |
257 amino acids |
| Molecular Weight |
28kDa |
| NCBI Gene Id |
23410 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Sirtuin 3 |
| Alias Symbols |
SIR2L3 |
| Peptide Sequence |
Synthetic peptide located within the following region: VGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGP |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Onyango,P., et al., (2002) Proc. Natl. Acad. Sci. U.S.A. 15 99(21), 13653-8 |
| Description of Target |
The SIRT3 gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT3 encodes a protein that is included in class I of the sirtuin family. |
| Protein Interactions |
SIRT5; SKP2; UBC; HSPD1; CMYA5; PGAP1; RIF1; NCAPD2; HERC2; TTF2; UQCRH; UGDH; HSP90B1; SNTB1; SBF1; HSPA9; HSPA5; HSPA4; HSPA1L; GRN; ATP5B; ATP5A1; SIRT4; tat; XRCC6; FOXO3; DNM1L; PEX5; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-SIRT3 (ARP32389_P050) antibody |
| Blocking Peptide |
For anti-SIRT3 (ARP32389_P050) antibody is Catalog # AAP32389 (Previous Catalog # AAPP03379) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human SIRT3 |
| Uniprot ID |
Q9NTG7 |
| Protein Name |
NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
| Publications |
Dong, R. et al. Cells with dendritic cell morphology and immunophenotype, binuclear morphology, and immunosuppressive function in dendritic cell cultures. Cell. Immunol. 272, 1-10 (2011). 22087287
Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas. Sci Adv. 2, e1601132 (2016). 27847869
Lanza, I. R. et al. Endurance exercise as a countermeasure for aging. Diabetes 57, 2933-42 (2008). 18716044 |
| Protein Accession # |
NP_001017524 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_001017524 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
SIRT3 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 79%; Guinea Pig: 79%; Horse: 86%; Human: 100%; Mouse: 86%; Rabbit: 100%; Rat: 79% |
| Image 1 | Human kidney
 | Human kidney |
|
| Image 2 | Human Thymus
 | WB Suggested Anti-SIRT3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Human Thymus |
|
| Image 3 | Human Lung
 | Rabbit Anti-SIRT3 Antibody
Catalog Number: ARP32389
Paraffin Embedded Tissue: Human alveolar cell
Cellular Data: Epithelial cells of renal tubule
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X |
|
