Catalog No: ARP32389_P050-Biotin
Size:100ul
Price: $434.00
SKU
ARP32389_P050-Biotin
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SIRT3 Antibody - C-terminal region : Biotin (ARP32389_P050-Biotin)

Datasheets/ManualsPrintable datasheet for anti-SIRT3 (ARP32389_P050-Biotin) antibody
Product Info
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer.
ClonalityPolyclonal
HostRabbit
ConjugationBiotin
ApplicationIHC, WB
Reconstitution and StorageAll conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
ImmunogenThe immunogen is a synthetic peptide directed towards the C terminal region of human SIRT3
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 79%; Guinea Pig: 79%; Horse: 86%; Human: 100%; Mouse: 86%; Rabbit: 100%; Rat: 79%
Peptide SequenceSynthetic peptide located within the following region: VGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGP
Concentration0.5 mg/ml
Blocking PeptideFor anti-SIRT3 (ARP32389_P050-Biotin) antibody is Catalog # AAP32389 (Previous Catalog # AAPP03379)
ReferenceOnyango,P., et al., (2002) Proc. Natl. Acad. Sci. U.S.A. 15 99(21), 13653-8
Publications

Lanza, I. R. et al. Endurance exercise as a countermeasure for aging. Diabetes 57, 2933-42 (2008). WB, Human, Rabbit, Bovine, Mouse, Horse, Rat, Dog, Guinea pig 18716044

Dong, R. et al. Cells with dendritic cell morphology and immunophenotype, binuclear morphology, and immunosuppressive function in dendritic cell cultures. Cell. Immunol. 272, 1-10 (2011). WB, Human, Rabbit, Bovine, Mouse, Horse, Rat, Dog, Guinea pig 22087287

Gene SymbolSIRT3
Gene Full NameSirtuin 3
Alias SymbolsSIR2L3
NCBI Gene Id23410
Protein NameNAD-dependent protein deacetylase sirtuin-3, mitochondrial
Description of TargetThe SIRT3 gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT3 encodes a protein that is included in class I of the sirtuin family.
Uniprot IDQ9NTG7
Protein Accession #NP_001017524
Nucleotide Accession #NM_001017524
Protein Size (# AA)257
Molecular Weight28kDa
Protein InteractionsSIRT5; SKP2; UBC; HSPD1; CMYA5; PGAP1; RIF1; NCAPD2; HERC2; TTF2; UQCRH; UGDH; HSP90B1; SNTB1; SBF1; HSPA9; HSPA5; HSPA4; HSPA1L; GRN; ATP5B; ATP5A1; SIRT4; tat; XRCC6; FOXO3; DNM1L; PEX5;
  1. What is the species homology for "SIRT3 Antibody - C-terminal region : Biotin (ARP32389_P050-Biotin)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit".

  2. How long will it take to receive "SIRT3 Antibody - C-terminal region : Biotin (ARP32389_P050-Biotin)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "SIRT3 Antibody - C-terminal region : Biotin (ARP32389_P050-Biotin)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "SIRT3 Antibody - C-terminal region : Biotin (ARP32389_P050-Biotin)"?

    This target may also be called "SIR2L3" in publications.

  5. What is the shipping cost for "SIRT3 Antibody - C-terminal region : Biotin (ARP32389_P050-Biotin)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "SIRT3 Antibody - C-terminal region : Biotin (ARP32389_P050-Biotin)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "SIRT3 Antibody - C-terminal region : Biotin (ARP32389_P050-Biotin)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "28kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "SIRT3 Antibody - C-terminal region : Biotin (ARP32389_P050-Biotin)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "SIRT3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "SIRT3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "SIRT3"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "SIRT3"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "SIRT3"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "SIRT3"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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