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Catalog No: OASA11552 (Formerly GWB-Q01401)
Size:25UG
Price: $149.00
SKU
OASA11552
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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  • $55 + $25/Kit in US
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Datasheets/ManualsPrintable datasheet for Rat anti-Human CD3 Antibody (OASA11552)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid. Phosphate buffered saline
ClonalityMonoclonal
CloneCD3-12
IsotypeIgG1
HostRat
ApplicationFC, IF, IHC-P, WB
Additional InformationHistology Positive Control Tissue: Tonsil
Carrier Free: Yes
Reconstitution and Storage-20°C
ImmunogenSynthetic peptide sequence derived from cytoplasmic epitope of CD3 (Glu-Arg-Pro-Pro-Pro-Val-Pro-Asn-Pro-Asp-Tyr-Glu-Pro-Cys) (ERPPPVPNPDYEPC )
PurificationPurified IgG prepared from tissue culture supernatant
Predicted Homology Based on Immunogen SequenceBovine, dog, horse, Rhesus monkey, pig, chicken, mouse, duck, koala, Harbour porpoise, alpaca, Cynomolgus monkey, spotted hyena, sea lion, cat, Amazon parrot, raccoon, great horned-owl, bullfrog, xenopus, rabbit. Based on sequence similarity, is expected to react with: mammals, birds, amphibia. Antibody reactivity and working conditions may vary between species. Antibody reactivity and working conditions may vary between species.
Concentration1 mg/ml
SpecificityRat anti Human CD3, clone CD3-12 raised against a peptide representing an invariant cytoplasmic sequence within the CD3-epilson chain recognizes human CD3-epsilon. As this product has been specifically raised against an epitope within the epsilon peptide chain, highly conserved among species clone CD3-12 has a very broad species crossreactivity for the CD3 marker.
Application InfoFC: 1/50-1/100. Membrane permeabilization is required for this application
IHC-F: 1/100
IHC-P: 1/100. This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Tris/EDTA buffer (pH 9.0) is recommended for this purpose.
Publications

Lack of Major Histocompatibility Complex Class I Upregulation and Restrictive Infection by JC Virus Hamper Detection of Neurons by T Lymphocytes in the Central Nervous System. J Neuropathol Exp Neurol. 74, 791-803 (2015). 26115192

Natalizumab-associated progressive multifocal leukoencephalopathy in a patient with multiple sclerosis: a postmortem study. J Neuropathol Exp Neurol. 72, 1043-51 (2013). 24128680

Reference1. Jones, M. et al. (1993). Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies. J. Immunol. 150 (12): 5429-5435.
2. Alterio, M. et al. (1998). Control of cytomeglavirus in bone marrow transplantation chimeras lacking the prevailing antigen-presenting molecule in recipient tissues rest primarily on recipient- derived CD8 T cells. J. Virol. 72 (10): 7733 - 7744
3. Burundi, E. et al. (2002). Regulation of indoeamine 2, 3-diooxygenase expression in Simian Immunodefiency Virus-infected monkey brains. J. Virol. 76 (3): 12233 - 12241.
Description
Alias SymbolsT3E, TCRE, IMD18
NCBI Gene Id916
Protein NameT-cell surface glycoprotein CD3 epsilon chain
Description of TargetCD3 is a multimeric protein complex composed of four distinct polypeptide chains (epsilon, gamma, delta, zeta) that assemble and function as three pairs of dimers (epsilon-gamma, epsilon-delta, zeta-zeta). The CD3 complex serves as a T-cell co-receptor that associates non-covalently with the T-cell receptor (TCR). CD3 is a defining feature of cells belonging to the T cell lineage and can therefore be used as a T-cell marker.
Uniprot IDP07766
Protein Accession #NP_000724.1
  1. What is the species homology for "Rat anti-Human CD3 Antibody (OASA11552)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "Rat anti-Human CD3 Antibody (OASA11552)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "Rat anti-Human CD3 Antibody (OASA11552)" provided in?

    This item is provided in "Liquid. Phosphate buffered saline".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Rat anti-Human CD3 Antibody (OASA11552)"?

    This target may also be called "T3E, TCRE, IMD18" in publications.

  5. What is the shipping cost for "Rat anti-Human CD3 Antibody (OASA11552)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Rat anti-Human CD3 Antibody (OASA11552)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Rat anti-Human CD3 Antibody (OASA11552)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Rat anti-Human CD3 Antibody (OASA11552)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for ""?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for ""?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with ""?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with ""?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with ""?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with ""?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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