Size:100 ul
Special Price $229.00 Regular Price $289.00
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ARP41283_P050
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Conjugation Options

ARP41283_P050-FITC Conjugated

ARP41283_P050-HRP Conjugated

ARP41283_P050-Biotin Conjugated

FZD8 Antibody - N-terminal region (ARP41283_P050)

Catalog#: ARP41283_P050
Domestic: within 1-2 days delivery | International: 1-2 days
More Information
Tested Species Reactivity Human
Predicted Species Reactivity Dog, Human, Mouse, Rat
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-33504 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human FZD8
Purification Affinity Purified
Predicted Homology Based on Immunogen Sequence Dog: 100%; Human: 100%; Mouse: 93%; Rat: 92%
Complete computational species homology data Anti-FZD8 (ARP41283_P050)
Peptide Sequence Synthetic peptide located within the following region: PDTLCMDYNRTDLTTAAPSPPRRLPPPPPGEQPPSGSGHGRPPGARPPHR
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-FZD8 (ARP41283_P050) antibody is Catalog # AAP41283 (Previous Catalog # AAPP22638)
Datasheets/Manuals Printable datasheet for anti-FZD8 (ARP41283_P050) antibody
Target Reference Lu,W., (2004) Cell 119 (1), 97-108
Publications

Xu, L; Wen, T; Liu, Z; Xu, F; Yang, L; Liu, J; Feng, G; An, G; MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8. 7, 40644-40656 (2016). WB, Dog, Human, Mouse, Rat 27276676

Gene Symbol FZD8
Official Gene Full Name Frizzled family receptor 8
Alias Symbols FZ-8, hFZ8
NCBI Gene Id 8325
Protein Name Frizzled-8
Description of Target FZD8 is a member of the frizzled family. Members of this family are seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
Swissprot Id Q9H461
Protein Accession # NP_114072
Nucleotide Accession # NM_031866
Protein Size (# AA) 694
Molecular Weight 73kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express FZD8.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express FZD8.
Protein Interactions WNT1; LRP5; LRP6; SUMO1; GOPC; RYK;
  1. What is the species homology for "FZD8 Antibody - N-terminal region (ARP41283_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Dog, Human, Mouse, Rat".

  2. How long will it take to receive "FZD8 Antibody - N-terminal region (ARP41283_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "FZD8 Antibody - N-terminal region (ARP41283_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "FZD8 Antibody - N-terminal region (ARP41283_P050)"?

    This target may also be called "FZ-8, hFZ8" in publications.

  5. What is the shipping cost for "FZD8 Antibody - N-terminal region (ARP41283_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "FZD8 Antibody - N-terminal region (ARP41283_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "FZD8 Antibody - N-terminal region (ARP41283_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "73kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "FZD8 Antibody - N-terminal region (ARP41283_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "FZD8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "FZD8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "FZD8"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "FZD8"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "FZD8"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "FZD8"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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