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FZD8 Antibody - N-terminal region (ARP41283_P050)

100 ul
$289.00
In Stock
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Conjugation Options

ARP41283_P050-FITC Conjugated

ARP41283_P050-HRP Conjugated

ARP41283_P050-Biotin Conjugated

Tested Species Reactivity:
Human
Predicted Species Reactivity:
Dog, Human, Mouse, Rat
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
FZD8
Official Gene Full Name:
Frizzled family receptor 8
NCBI Gene Id:
8325
Protein Name:
Frizzled-8
Swissprot Id:
Q9H461
Protein Accession #:
NP_114072
Nucleotide Accession #:
NM_031866
Alias Symbols:
FZ-8, hFZ8
Replacement Item:
This antibody may replace item sc-33504 from Santa Cruz Biotechnology.
Description of Target:
FZD8 is a member of the frizzled family. Members of this family are seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
Protein Size (# AA):
694
Molecular Weight:
73kDa
Purification:
Affinity Purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express FZD8.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express FZD8.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human FZD8
Predicted Homology Based on Immunogen Sequence:
Dog: 100%; Human: 100%; Mouse: 93%; Rat: 92%
Complete computational species homology data:
Anti-FZD8 (ARP41283_P050)
Peptide Sequence:
Synthetic peptide located within the following region: PDTLCMDYNRTDLTTAAPSPPRRLPPPPPGEQPPSGSGHGRPPGARPPHR
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
WNT1; LRP5; LRP6; SUMO1; GOPC; RYK;
Blocking Peptide:
For anti-FZD8 (ARP41283_P050) antibody is Catalog # AAP41283 (Previous Catalog # AAPP22638)
Datasheets/Manuals:
Printable datasheet for anti-FZD8 (ARP41283_P050) antibody
Target Reference:
Lu,W., (2004) Cell 119 (1), 97-108
Publications:

Xu, L; Wen, T; Liu, Z; Xu, F; Yang, L; Liu, J; Feng, G; An, G; MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8. 7, 40644-40656 (2016). WB, Dog, Human, Mouse, Rat 27276676

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