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Goat Anti-FZD8 / frizzled 8 Antibody (OAEB02431)

100 ug
$349.00
In Stock
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Gene Symbol:
FZD8
NCBI Gene Id:
8325
Protein Name:
Frizzled-8
Swissprot Id:
Q9H461
Protein Accession #:
NP_114072.1
Alias Symbols:
FZD8, frizzled homolog 8 (Drosophila), HGNC:4046, FZ-8, hFZ8, frizzled (Drosophila) homolog 8, frizzled 8
Replacement Item:
This antibody may replace item sc-33504 from Santa Cruz Biotechnology.
Molecular Weight:
73.3 kDa
Host:
Goat
Clonality:
Polyclonal
Purification:
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Application:
WB, IHC, P-ELISA
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express FZD8.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express FZD8.
Immunogen:
Peptide with sequence C-SYPKQMPLSQV, from the C Terminus of the protein sequence according to NP_114072.1.
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Human: 100%; Mouse: 100%; Rat: 100%
Complete computational species homology data:
FZD8 Antibody (OAEB02431)
Peptide Sequence:
C-SYPKQMPLSQV
Product Format:
Liquid. Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Reconstitution and Storage:
Aliquot and store at -20C. Minimize freezing and thawing.
Concentration:
0.5 mg/ml
Datasheets/Manuals:
Printable datasheet for anti-FZD8 antibody - OAEB02431
Intended Use:
Research use only. Not for diagnostic or therapeutic use.
Application Info:
P-ELISA: Antibody detection limit dilution 1:32000
WB: Approx 75kDa band observed in human heart and human pancreas lysates (calculated MW of 73.3kDa according to NP_114072.1). Recommended concentration: 1-3ug/ml.
IHC: In paraffin embedded Human Pancreas, shows granular cytoplasmic staining of acinar cells. Cells of the Islets of Langerhans are weakly stained, if at all. Recommended concentration, 3ug/ml.
Target Reference:
* Keay SK, Szekely Z, Conrads TP, Veenstra TD, Barchi JJ Jr, Zhang CO, Koch KR, Michejda CJ.; An antiproliferative factor from interstitial cystitis patients is a frizzled 8 protein-related sialoglycopeptide.; Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11803-8. Epub 2004 Jul 28.; Pubmed 15282374
Publications:

Yin, S. et al. Tumor-initiating cells and FZD8 play a major role in drug resistance in triple-negative breast cancer. Mol. Cancer Ther. 12, 491-8 (2013). WB, IHC, P-ELISA, Human 23445611

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