FZD8 Antibody - N-terminal region : Biotin (ARP41283_P050-Biotin)

Catalog No: ARP41283_P050-Biotin

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Dog
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Biotin
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FZD8
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Dog: 100%; Human: 100%; Mouse: 93%; Rat: 92%
• Peptide Sequence: Synthetic peptide located within the following region: PDTLCMDYNRTDLTTAAPSPPRRLPPPPPGEQPPSGSGHGRPPGARPPHR
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-FZD8 (ARP41283_P050-Biotin) antibody is Catalog # AAP41283 (Previous Catalog # AAPP22638)
• Reference: Lu,W., (2004) Cell 119 (1), 97-108
• Publications:

  Anti-FZD8 ARP41283_P050 has recently been referenced in the following publications:

  Yin, S. et al. Tumor-initiating cells and FZD8 play a major role in drug resistance in triple-negative breast cancer. Mol. Cancer Ther. 12, 491–8 (2013). 23445611

Target Info

• Gene Symbol: FZD8
• Gene Full Name: Frizzled family receptor 8
• Alias Symbols: FZ-8, hFZ8
• NCBI Gene Id: 8325
• Protein Name: Frizzled-8
• Description of Target: FZD8 is a member of the frizzled family. Members of this family are seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
• Uniprot ID: Q9H461
• Protein Accession #: NP_114072
• Nucleotide Accession #: NM_031866
• Protein Size (# AA): 694
• Molecular Weight: 73kDa
• Protein Interactions: WNT1; LRP5; LRP6; SUMO1; GOPC; RYK;