Product Number |
ARP41283_P050 |
Product Page |
www.avivasysbio.com/fzd8-antibody-n-terminal-region-arp41283-p050.html |
Name |
FZD8 Antibody - N-terminal region (ARP41283_P050) |
Protein Size (# AA) |
694 amino acids |
Molecular Weight |
73kDa |
NCBI Gene Id |
8325 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Frizzled family receptor 8 |
Alias Symbols |
FZ-8, hFZ8 |
Peptide Sequence |
Synthetic peptide located within the following region: PDTLCMDYNRTDLTTAAPSPPRRLPPPPPGEQPPSGSGHGRPPGARPPHR |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Lu,W., (2004) Cell 119 (1), 97-108 |
Description of Target |
FZD8 is a member of the frizzled family. Members of this family are seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. |
Protein Interactions |
WNT1; LRP5; LRP6; SUMO1; GOPC; RYK; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-FZD8 (ARP41283_P050) antibody |
Blocking Peptide |
For anti-FZD8 (ARP41283_P050) antibody is Catalog # AAP41283 (Previous Catalog # AAPP22638) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human FZD8 |
Uniprot ID |
Q9H461 |
Protein Name |
Frizzled-8 |
Publications |
MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8. Oncotarget. 7, 40644-40656 (2016). 27276676 |
Protein Accession # |
NP_114072 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_031866 |
Tested Species Reactivity |
Human |
Gene Symbol |
FZD8 |
Predicted Species Reactivity |
Human, Mouse, Rat, Dog |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Dog: 100%; Human: 100%; Mouse: 93%; Rat: 92% |
Image 1 | Human 721_B
| Host: Rabbit Target Name: FZD8 Sample Tissue: Human 721_B Antibody Dilution: 1.0ug/ml |
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