FZD8 Antibody - N-terminal region (ARP41283_P050)

Data Sheet
 
Product Number ARP41283_P050
Product Page www.avivasysbio.com/fzd8-antibody-n-terminal-region-arp41283-p050.html
Name FZD8 Antibody - N-terminal region (ARP41283_P050)
Protein Size (# AA) 694 amino acids
Molecular Weight 73kDa
NCBI Gene Id 8325
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Frizzled family receptor 8
Alias Symbols FZ-8, hFZ8
Peptide Sequence Synthetic peptide located within the following region: PDTLCMDYNRTDLTTAAPSPPRRLPPPPPGEQPPSGSGHGRPPGARPPHR
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Lu,W., (2004) Cell 119 (1), 97-108
Description of Target FZD8 is a member of the frizzled family. Members of this family are seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
Protein Interactions WNT1; LRP5; LRP6; SUMO1; GOPC; RYK;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-FZD8 (ARP41283_P050) antibody
Blocking Peptide For anti-FZD8 (ARP41283_P050) antibody is Catalog # AAP41283 (Previous Catalog # AAPP22638)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human FZD8
Uniprot ID Q9H461
Protein Name Frizzled-8
Publications

MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8. Oncotarget. 7, 40644-40656 (2016). 27276676

Protein Accession # NP_114072
Purification Affinity Purified
Nucleotide Accession # NM_031866
Tested Species Reactivity Human
Gene Symbol FZD8
Predicted Species Reactivity Human, Mouse, Rat, Dog
Application WB
Predicted Homology Based on Immunogen Sequence Dog: 100%; Human: 100%; Mouse: 93%; Rat: 92%
Image 1
Human 721_B
Host: Rabbit
Target Name: FZD8
Sample Tissue: Human 721_B
Antibody Dilution: 1.0ug/ml
 

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