TARDBP Recombinant Protein (OPCD07319)

Catalog No: OPCD07319

TARDBP Recombinant Protein (OPCD07319) using SDS-PAGE

TARDBP Recombinant Protein (OPCD07319) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ser104-Pro262
  Subcellular Location: Nucleus
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: TARDBP
• Gene Full Name: TAR DNA binding protein
• Alias Symbols: ALS10;TAR DNA-binding protein 43;TAR DNA-binding protein-43;TDP-43.
• NCBI Gene Id: 23435
• Protein Name: TAR DNA-binding protein 43
• Description of Target: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.
• Uniprot ID: Q13148
• Protein Accession #: NP_031401.1
• Nucleotide Accession #: NM_007375.3
• Protein Size (# AA): Ser104~Pro262
• Molecular Weight: 21/19kDa