Size:100 ul
Special Price $229.00 Regular Price $289.00
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ARP37978_P050
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Conjugation Options

ARP37978_P050-FITC Conjugated

ARP37978_P050-HRP Conjugated

ARP37978_P050-Biotin Conjugated

MITF Antibody - middle region (ARP37978_P050)

Catalog#: ARP37978_P050
Domestic: within 1-2 days delivery | International: 1-2 days
More Information
Tested Species ReactivityHuman, Mouse
Predicted Species ReactivityCow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement ItemThis antibody may replace item sc-10999 from Santa Cruz Biotechnology.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human MITF
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100%
Complete computational species homology dataAnti-MITF (ARP37978_P050)
Peptide SequenceSynthetic peptide located within the following region: MGSKLEDILMDDTLSPVGVTDPLLSSVSPGASKTSSRRSSMSMEETEHTC
ConcentrationBatch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking PeptideFor anti-MITF (ARP37978_P050) antibody is Catalog # AAP37978 (Previous Catalog # AAPP20081)
Datasheets/ManualsPrintable datasheet for anti-MITF (ARP37978_P050) antibody
Sample Type Confirmation

MITF is supported by BioGPS gene expression data to be expressed in HeLa

Target ReferenceChiaverini,C., (2008) J. Biol. Chem. 283 (18), 12635-12642
Publications

Ursini, G; Cavalleri, T; Fazio, L; Angrisano, T; Iacovelli, L; Porcelli, A; Maddalena, G; Punzi, G; Mancini, M; Gelao, B; Romano, R; Masellis, R; Calabrese, F; Rampino, A; Taurisano, P; Di Giorgio, A; Keller, S; Tarantini, L; Sinibaldi, L; Quarto, T; Popolizio, T; Caforio, G; Blasi, G; Riva, MA; De Blasi, A; Chiariotti, L; Bollati, V; Bertolino, A; BDNF rs6265 methylation and genotype interact on risk for schizophrenia. 11, 11-23 (2016). WB, Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish 26889735

Gene SymbolMITF
Official Gene Full NameMicrophthalmia-associated transcription factor
Alias SymbolsWS2A, MI, WS2, bHLHe32
NCBI Gene Id4286
Protein NameMicrophthalmia-associated transcription factor
Description of TargetMITF is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Swissprot IdO75030-9
Protein Accession #NP_000239
Nucleotide Accession #NM_000248
Protein Size (# AA)419
Molecular Weight47kDa
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express MITF.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express MITF.
Protein InteractionsEBP; STUB1; HK3; EPAS1; LEF1; APP; HINT1; ELAVL1; CDK2; SUMO2; PSMD14; MARK3; PIAS3; PIAS2; PIAS1; SUMO1; UBE2I; PAX3; OTX2; PAX6; PATZ1; GSK3B; TFEC; EP300; RPS6KA1; TFEB; MAPK14; TFE3; MAPK1; SPI1; FOS; CTNNB1; CDKN1A; RB1;
  1. What is the species homology for "MITF Antibody - middle region (ARP37978_P050)"?

    The tested species reactivity for this item is "Human, Mouse". This antibody is predicted to have homology to "Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish".

  2. How long will it take to receive "MITF Antibody - middle region (ARP37978_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "MITF Antibody - middle region (ARP37978_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "MITF Antibody - middle region (ARP37978_P050)"?

    This target may also be called "WS2A, MI, WS2, bHLHe32" in publications.

  5. What is the shipping cost for "MITF Antibody - middle region (ARP37978_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "MITF Antibody - middle region (ARP37978_P050)"?

    All Aviva products have been through vigorous validations and carry 100% satisfaction warranty.

  7. Can I get bulk pricing for "MITF Antibody - middle region (ARP37978_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "47kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "MITF Antibody - middle region (ARP37978_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "MITF"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "MITF"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "MITF"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "MITF"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "MITF"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "MITF"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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