| Sku |
AAP37978 |
| Old sku |
AAPP20081 |
| Price |
$99.00 |
| Name |
MITF Peptide - middle region (AAP37978) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
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- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
MITF |
| Alias symbols |
WS2A, MI, WS2, bHLHe32 |
| Gene id |
4286 |
| Description of target |
MITF is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Swissprot id |
O75030-9 |
| Protein accession num |
NP_000239 |
| Nucleotide accession num |
NM_000248 |
| Protein size |
419 amino acids |
| Molecular weight |
47kDa |
| Application |
WB |
| Partner proteins |
CTNNB1,EP300,FOS,GSK3B,LEF1,MAPK1,MAPK14,OTX2,PATZ1,PAX3,PAX6,PIAS3,RPS6KA1,SPI1,SUMO1,TFE3,TFEB,TFEC,UBE2I,CDK2,CDKN1A,FOS,LEF1,PATZ1,PAX6,PIAS3,RB1,SPI1,TFE3,TFEC,UBE2I |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Chiaverini,C., (2008) J. Biol. Chem. 283 (18), 12635-12642 |
| Description |
This is a synthetic peptide designed for use in combination with anti-MITF antibody (Catalog #: ARP37978_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
