IL-13 Antibody (OADB00325)

Catalog No: OADB00325

Size:500 ug

Product Info

• Predicted Species Reactivity: Human
• Product Format: Lyophilized
• Clonality: Monoclonal
• Clone: B-B13
• Isotype: Mouse IgG1
• Host: Mouse
• Application: BL, FC
• Reconstitution and Storage: Store at +2-8C for 12 months. For longer storage, freeze aliquots
• Purification: Ion exchange chromatography
• Concentration: 1 ug/uL
• Specificity: Recognises both natural and recombinant human IL-13
• Formulation: Phosphate-buffered saline. Sterile-filtered through 0.22 um and treated to remove endotoxins. Carrier and preservative free
• Storage Buffer: Phosphate-buffered saline. Sterile-filtered through 0.22 um and treated to remove endotoxins. Carrier and preservative free
• Reference: Guillot C. et al., Blood, 2003; 101 : 3325 - 3333
  van der Pouw Kraan, T. C. et al., J Immunol.,1996; 156(5): 1818-23.
  Woerly, G. et al.,J Leukoc Biol.,2002; 72(4): 769-79.
• Biological Activity: Blocks IL-13 induced proliferation on TF1 cell line

Target Info

• Gene Symbol: IL-13
• Gene Full Name: interleukin 13
• Alias Symbols: P600, IL-13
• NCBI Gene Id: 3596
• Protein Name: interleukin-13
• Description of Target: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
• Uniprot ID: P35225
• Protein Accession #: NP_002179.2
• Nucleotide Accession #: NM_002188.2
• Molecular Weight: 16 kDa