CYP3A4 Recombinant Protein (OPCD02620)

Catalog No: OPCD02620

CYP3A4 Recombinant Protein (OPCD02620) using SDS-PAGE

CYP3A4 Recombinant Protein (OPCD02620) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Pro344-Asp497
  Subcellular Location: Membrane
  Isoelectric Point: 9.4
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 90%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: CYP3A4
• Gene Full Name: cytochrome P450 family 3 subfamily A member 4
• Alias Symbols: 1,4-cineole 2-exo-monooxygenase;1,8-cineole 2-exo-monooxygenase;Albendazole monooxygenase;albendazole monooxygenase (sulfoxide-forming);albendazole sulfoxidase;cholesterol 25-hydroxylase;CP33;CP34;CYP3A;CYP3A3;CYPIIIA3;CYPIIIA4;cytochrome P450 3A3;cytochrome P450 3A4;cytochrome P450 HLp;cytochrome P450 NF-25;cytochrome P450, family 3, subfamily A, polypeptide 4;cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3;cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4;cytochrome P450-PCN1;glucocorticoid-inducible P450;HLP;NF-25;nifedipine oxidase;P450C3;P450-III, steroid inducible;P450PCN1;quinine 3-monooxygenase;taurochenodeoxycholate 6-alpha-hydroxylase;VDDR3.
• NCBI Gene Id: 1576
• Protein Name: Cytochrome P450 3A4
• Description of Target: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).
• Uniprot ID: P08684
• Protein Accession #: NP_001189784.1
• Nucleotide Accession #: NM_001202855.2
• Protein Size (# AA): Pro344~Asp497
• Molecular Weight: 22kDa