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Now Offering Over 102,157 Antibodies & 44,722 Antigens!

CYBB Antibody (OACA02822)

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Gene Symbol:
CYBB
NCBI Gene Id:
1536
Official Gene Full Name:
cytochrome b-245 beta chain
Protein Name:
Cytochrome b-245 heavy chain
Swissprot Id:
P04839
Protein Accession #:
NP_000388
Nucleotide Accession #:
NM_000397
Alias Symbols:
CGD, CGD91-phox, Cytochrome b(558) subunit beta, Cytochrome b-245 heavy chain, Cytochrome b558 subunit beta, gp91-1, GP91-1, GP91PHOX, gp91-phox, GP91-PHOX, Heme-binding membrane glycoprotein gp91phox, NADPH oxidase 2, Neutrophil cytochrome b 91 kDa polyp
Replacement Item:
This antibody may replace item sc-5826 from Santa Cruz Biotechnology.
Description of Target:
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H+ currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Caprylic Acid Ammonium Sulfate Precipitation purified
Application:
ELISA, IHC, IF
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CYBB.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CYBB.
Immunogen:
Recombinant human Cytochrome b-245 heavy chain protein (283-570AA)
Species Reactivity:
Human
Product Format:
Liquid
Reconstitution and Storage:
Shipped at 4C. Upon delivery aliquot and store at -20C or -80C. Avoid repeated freeze.
Datasheets/Manuals:
Printable datasheet for anti-CYBB (OACA02822) antibody
Preservative:
0.03% Proclin 300
Formulation:
50% Glycerol, 0.01M PBS, PH 7.4
Isotype:
IgG
Target Reference:
[1]"Clinical, functional, and genetic characterization of chronic granulomatous disease in 89 Turkish patients." Koeker M.Y., Camcioglu Y., van Leeuwen K., Kilic S.S., Barlan I., Yilmaz M., Metin A., de Boer M., Avcilar H., Patiroglu T., Yildiran A., Yegin O., Tezcan I., Sanal O., Roos D. J. Allergy Clin. Immunol. 132:1156-1163(2013). [2]"Identification and functional characterization of two novel mutations in the alpha-helical loop (residues 484-503) of CYBB/gp91(phox) resulting in the rare X91(+) variant of chronic granulomatous disease." Boog B., Quach A., Costabile M., Smart J., Quinn P., Singh H., Gold M., Booker G., Choo S., Hii C.S., Ferrante A. Hum. Mutat. 33:471-475(2012). [3]"Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease." Bustamante J., Arias A.A., Vogt G., Picard C., Galicia L.B., Prando C., Grant A.V., Marchal C.C., Hubeau M., Chapgier A., de Beaucoudrey L., Puel A., Feinberg J., Valinetz E., Janniere L., Besse C., Boland A., Brisseau J.M. Casanova J.L. Nat. Immunol. 12:213-221(2011).
Protocol:
Tips Information:

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