| Product Number |
OACA02822 |
| Product Page |
www.avivasysbio.com/cybb-antibody-oaca02822.html |
| Name |
CYBB Antibody (OACA02822) |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
1536 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Gene Full Name |
cytochrome b-245 beta chain |
| Alias Symbols |
AMCBX2;CGD;CGD91-phox;CGDX;cytochrome b(558) subunit beta;cytochrome b-245 beta polypeptide;cytochrome b-245 heavy chain;cytochrome b558 subunit beta;GP91-1;GP91PHOX;GP91-PHOX;heme-binding membrane glycoprotein gp91phox;IMD34;NADPH oxidase 2;neutrophil cytochrome b 91 kDa polypeptide;NOX2;p22 phagocyte B-cytochrome;p91-PHOX;superoxide-generating NADPH oxidase heavy chain subunit. |
| Product Format |
Liquid |
| Reference |
[1]"Clinical, functional, and genetic characterization of chronic granulomatous disease in 89 Turkish patients." Koeker M.Y., Camcioglu Y., van Leeuwen K., Kilic S.S., Barlan I., Yilmaz M., Metin A., de Boer M., Avcilar H., Patiroglu T., Yildiran A., Yegin O., Tezcan I., Sanal O., Roos D. J. Allergy Clin. Immunol. 132:1156-1163(2013). [2]"Identification and functional characterization of two novel mutations in the alpha-helical loop (residues 484-503) of CYBB/gp91(phox) resulting in the rare X91(+) variant of chronic granulomatous disease." Boog B., Quach A., Costabile M., Smart J., Quinn P., Singh H., Gold M., Booker G., Choo S., Hii C.S., Ferrante A. Hum. Mutat. 33:471-475(2012). [3]"Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease." Bustamante J., Arias A.A., Vogt G., Picard C., Galicia L.B., Prando C., Grant A.V., Marchal C.C., Hubeau M., Chapgier A., de Beaucoudrey L., Puel A., Feinberg J., Valinetz E., Janniere L., Besse C., Boland A., Brisseau J.M. Casanova J.L. Nat. Immunol. 12:213-221(2011). |
| Description of Target |
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. |
| Reconstitution and Storage |
-20°C or -80°C |
| Datasheets/Manuals |
Printable datasheet for CYBB Antibody (OACA02822) (OACA02822) |
| Immunogen |
Recombinant Human Cytochrome b-245 heavy chain protein (283-570AA) |
| Formulation |
50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot ID |
P04839 |
| Protein Name |
Cytochrome b-245 heavy chain |
| Protein Accession # |
NP_000388 |
| Purification |
Protein G Purified |
| Nucleotide Accession # |
NM_000397 |
| Preservative |
0.03% Proclin 300 |
| Gene Symbol |
CYBB |
| Predicted Species Reactivity |
Human |
| Application |
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry |
| Image 1 | Human brain tissue
 | Immunohistochemistry of paraffin-embedded human brain tissue at dilution 1:100 |
| | Image 2 | Human tonsil tissue
 | Immunohistochemistry of paraffin-embedded human tonsil tissue at dilution 1:100 |
| | Image 3 | Hela cells
 | Immunofluorescent analysis of Hela cells at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) |
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