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COPA Antibody - N-terminal region (ARP51893_P050)

100 ul
$319.00
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Conjugation Options

ARP51893_P050-FITC Conjugated

ARP51893_P050-HRP Conjugated

ARP51893_P050-Biotin Conjugated

Gene Symbol:
COPA
Official Gene Full Name:
Coatomer protein complex, subunit alpha
NCBI Gene Id:
1314
Protein Name:
Coatomer subunit alpha
Swissprot Id:
P53621
Protein Accession #:
NP_004362
Nucleotide Accession #:
NM_004371
Alias Symbols:
FLJ26320, HEP-COP
Replacement Item:
This antibody may replace item sc-133474 from Santa Cruz Biotechnology.
Description of Target:
In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone.In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms.
Protein Size (# AA):
1224
Molecular Weight:
135kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express COPA.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express COPA.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human COPA
Predicted Species Reactivity:
Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Goat: 86%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 93%; Zebrafish: 100%
Complete computational species homology data:
Anti-COPA (ARP51893_P050)
Peptide Sequence:
Synthetic peptide located within the following region: PWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGD
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBC; SUMO2; SMN1; STAU1; NUDCD1; SUMO1; NEDD8; RPA3; RPA2; RPA1; SUZ12; RNF2; COPZ1; DHX38; COPB2; CCT3; TCP1; SEPT2; ARCN1; UBD; VCAM1; ITGA4; COPB1; COPG2; COPG1; COPE; SEPT9; SEC23A; SEC24C; UBXN6; FBXO6; LMAN1; SACM1L; DDX20; TMED10; GEMIN2; COPA; CDK
Blocking Peptide:
For anti-COPA (ARP51893_P050) antibody is Catalog # AAP51893 (Previous Catalog # AAPP40072)
Datasheets/Manuals:
Printable datasheet for anti-COPA (ARP51893_P050) antibody
Sample Type Confirmation:

COPA is strongly supported by BioGPS gene expression data to be expressed in HeLa

Subunit:
alpha
Target Reference:
Olsen,J.V., (2006) Cell 127 (3), 635-648
Publications:

Li, H; Custer, SK; Gilson, T; Hao, le T; Beattie, CE; Androphy, EJ; α-COP binding to the survival motor neuron protein SMN is required for neuronal process outgrowth. 24, 7295-307 (2015). WB, Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish 26464491

Ting, C.-H. et al. The spinal muscular atrophy disease protein SMN is linked to the Golgi network. PLoS One 7, e51826 (2012). WB, Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish 23284781

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