CDK8 Antibody - N-terminal region (OAAB17085)

Catalog No: OAAB17085

Size:400ul

Western blot analysis of CDK8 antibody (N-term) (Cat.# OAAB17085) in Jurkat cell line lysates (35ug/lane). CDK8 (arrow) was detected using the purified Pab.

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Mouse
• Product Format: Liquid PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB, ELISA
• Additional Information: Cellular Location: Nucleus
• Reconstitution and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This CDK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CDK8.
• Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Concentration: 2 mg/ml
• Application Info: WB: 1:1000

Target Info

• Gene Symbol: CDK8
• Alias Symbols: K35, IDDHBA
• NCBI Gene Id: 1024
• Protein Name: Cyclin-dependent kinase 8
• Description of Target: CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
• Uniprot ID: P49336
• Protein Accession #: NP_001251.1
• Molecular Weight: 53 kDa