Product Number |
OAAB17085 |
Product Page |
www.avivasysbio.com/cdk8-antibody-n-terminal-region-oaab17085.html |
Name |
CDK8 Antibody - N-terminal region (OAAB17085) |
Molecular Weight |
53 kDa |
Isotype |
Ig |
NCBI Gene Id |
1024 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
2 mg/ml |
Alias Symbols |
K35, IDDHBA |
Product Format |
Liquid PBS with 0.09% (W/V) sodium azide. |
Description of Target |
CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. |
Reconstitution and Storage |
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for OAAB17085 |
Additional Information |
Cellular Location: Nucleus |
Application Info |
WB: 1:1000 |
Immunogen |
This CDK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CDK8. |
Uniprot ID |
P49336 |
Protein Name |
Cyclin-dependent kinase 8 |
Protein Accession # |
NP_001251.1 |
Purification |
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Tested Species Reactivity |
Human |
Gene Symbol |
CDK8 |
Predicted Species Reactivity |
Mouse |
Application |
WB, ELISA |
Image 1 | CDK8, Jurkat
| Western blot analysis of CDK8 antibody (N-term) (Cat.# OAAB17085) in Jurkat cell line lysates (35ug/lane). CDK8 (arrow) was detected using the purified Pab. |
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