CDK8 Antibody - N-terminal region (OAAB17085)

Data Sheet
 
Product Number OAAB17085
Product Page www.avivasysbio.com/cdk8-antibody-n-terminal-region-oaab17085.html
Name CDK8 Antibody - N-terminal region (OAAB17085)
Molecular Weight 53 kDa
Isotype Ig
NCBI Gene Id 1024
Host Rabbit
Clonality Polyclonal
Concentration 2 mg/ml
Alias Symbols K35, IDDHBA
Product Format Liquid PBS with 0.09% (W/V) sodium azide.
Description of Target CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
Reconstitution and Storage Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB17085
Additional Information Cellular Location: Nucleus
Application Info WB: 1:1000
Immunogen This CDK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CDK8.
Uniprot ID P49336
Protein Name Cyclin-dependent kinase 8
Protein Accession # NP_001251.1
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Tested Species Reactivity Human
Gene Symbol CDK8
Predicted Species Reactivity Mouse
Application WB, ELISA
Image 1
CDK8, Jurkat
Western blot analysis of CDK8 antibody (N-term) (Cat.# OAAB17085) in Jurkat cell line lysates (35ug/lane). CDK8 (arrow) was detected using the purified Pab.
 

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