CDK8 Recombinant Protein (OPCD02105)

Catalog No: OPCD02105

CDK8 Recombinant Protein (OPCD02105) using SDS-PAGE

CDK8 Recombinant Protein (OPCD02105) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Glu21-Asp392
  Subcellular Location: Nucleus
  Isoelectric Point: 8.5
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 150 ug/mL (prior to lyoph)
• Purity: >95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: CDK8
• Gene Full Name: cyclin dependent kinase 8
• Alias Symbols: CDK8 protein kinase;cell division protein kinase 8;cyclin-dependent kinase 8;IDDHBA;K35;mediator complex subunit CDK8;mediator of RNA polymerase II transcription subunit CDK8;protein kinase K35.
• NCBI Gene Id: 1024
• Protein Name: Cyclin-dependent kinase 8
• Description of Target: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.
• Uniprot ID: P49336
• Protein Accession #: NP_001251.1
• Nucleotide Accession #: NM_001260.2
• Protein Size (# AA): Glu21~Asp392
• Molecular Weight: 47kDa