ACVR2A Antibody - N-terminal region (OAAB16873)

Catalog No: OAAB16873

Size:400ul

ACVR2A is an activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

Western blot analysis of anti-ACVR2A Antibody (N-term) (Cat. # OAAB16873) in mouse liver(lane 1) brain(lane 2) and kidney(lane 3) tissue lysates (35ug/lane). ACVR2A (arrow) was detected using the purified Pab.

ACVR2A is strongly supported by BioGPS gene expression data to be expressed in HEK293

Western blot analysis of ACVR2A (arrow) using rabbit polyclonal ACVR2A Antibody (N-term) (Cat.# OAAB16873). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACVR2A gene (Lane 2) (Origene Technologies).

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Product Info

• Predicted Species Reactivity: Human, Mouse, Bovine, Chicken, Rat, Sheep
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB, IHC-P
• Additional Information: Cellular Location: Membrane; Single-pass type I membrane protein.
• Reconstitution and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This ACVR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-29 amino acids from the N-terminal region of human ACVR2A.
• Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Concentration: Varies by lot. See vial for concentration.
• Sample Type Confirmation:

  ACVR2A is strongly supported by BioGPS gene expression data to be expressed in HEK293

• Intended Use: ACVR2A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
• Application Info: WB: 1:2000

Target Info

• Gene Symbol: ACVR2A
• Alias Symbols: ACVR2, ACTRII
• NCBI Gene Id: 92
• Protein Name: Activin receptor type-2A
• Description of Target: ACVR2A is an activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
• Uniprot ID: P27037
• Protein Accession #: NP_001607.1
• Molecular Weight: 57848 Da