ACVR2A Antibody - N-terminal region (OAAB16873)

• Product Number: OAAB16873
• Name: ACVR2A Antibody - N-terminal region (OAAB16873)
• Molecular Weight: 57848 Da
• Isotype: Ig
• NCBI Gene Id: 92
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: Varies by lot. See vial for concentration.
• Description:
  View product citations for ACVR2A Antibody - N-terminal region (OAAB16873) on CiteAb
• Alias Symbols: ACVR2, ACTRII
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Description of Target: ACVR2A is an activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
• Reconstitution and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Additional Information: Cellular Location: Membrane; Single-pass type I membrane protein.
• Application Info: WB: 1:2000
• Immunogen: This ACVR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-29 amino acids from the N-terminal region of human ACVR2A.
• Intended Use: ACVR2A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
• Uniprot ID: P27037
• Protein Name: Activin receptor type-2A
• Sample Type Confirmation:

  ACVR2A is strongly supported by BioGPS gene expression data to be expressed in HEK293

• Protein Accession #: NP_001607.1
• Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Gene Symbol: ACVR2A
• Predicted Species Reactivity: Human, Mouse, Bovine, Chicken, Rat, Sheep
• Application: WB, IHC-P
• Image 1: Mouse Liver, brain, Kidney,
  
  Western blot analysis of anti-ACVR2A Antibody (N-term) (Cat. # OAAB16873) in mouse liver(lane 1) brain(lane 2) and kidney(lane 3) tissue lysates (35ug/lane). ACVR2A (arrow) was detected using the purified Pab.

  ACVR2A is strongly supported by BioGPS gene expression data to be expressed in HEK293

• Image 2: 293
  
  Western blot analysis of ACVR2A (arrow) using rabbit polyclonal ACVR2A Antibody (N-term) (Cat.# OAAB16873). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACVR2A gene (Lane 2) (Origene Technologies).
• Image 3: hepatocarcinoma
  
  Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.