Catalog No: OPCD07986
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SKU
OPCD07986
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Datasheets/ManualsPrintable datasheet for XPO1 Recombinant Protein (OPCD07986)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Thr917-Asp1071
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity>95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolXPO1
Gene Full Nameexportin 1
Alias Symbolschromosome region maintenance 1 homolog;chromosome region maintenance 1 protein homolog;CRM1;CRM-1;emb;exp1;exportin 1 (CRM1 homolog, yeast);exportin-1;exportin-1 (required for chromosome region maintenance).
NCBI Gene Id7514
Protein NameExportin-1
Description of TargetMediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.
Uniprot IDO14980
Protein Accession #NP_003391.1
Nucleotide Accession #NM_003400.3
Protein Size (# AA)Thr917~Asp1071
Molecular Weight21kDa
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