TNFRSF11B Recombinant Protein (OPCD08039)

Catalog No: OPCD08039

TNFRSF11B Recombinant Protein (OPCD08039) using SDS-PAGE

TNFRSF11B Recombinant Protein (OPCD08039) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 5% Trehalose.
• Host: 293F cell
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Tyr31-Leu401
  Subcellular Location: Secreted
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: 293-F Cells
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: TNFRSF11B
• Gene Full Name: TNF receptor superfamily member 11b
• Alias Symbols: OCIF;OPG;osteoclastogenesis inhibitory factor;osteoprotegerin;PDB5;TR1;tumor necrosis factor receptor superfamily member 11B;tumor necrosis factor receptor superfamily, member 11b.
• NCBI Gene Id: 4982
• Protein Name: Tumor necrosis factor receptor superfamily member 11B
• Description of Target: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
• Uniprot ID: O00300
• Protein Accession #: NP_002537.3
• Nucleotide Accession #: NM_002546.3
• Protein Size (# AA): Tyr31~Leu401
• Molecular Weight: 42kDa