Loading...
Catalog No: OABF00746
Size:100UL
Price: $409.00
SKU
OABF00746
Availability: 3 to 5 business days.
Bulk
Order
Aviva's
Satisfaction
Guarantee
Contact Us:
Shipping Info:
  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
  • Contact us for international orders.

STK11 Antibody (Phospho-Thr363) (OABF00746)

Datasheets/ManualsPrintable datasheet for STK11 Antibody (Phospho-Thr363) (OABF00746)
Product Info
Predicted Species ReactivityBovine|Chicken|Dog|Horse|Human|Mouse|Rat
Product FormatLiquid. Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationUnconjugated
ApplicationEnzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin
Additional InformationSubcellular Location: Cytoplasm, Nucleus, Mitochondrion, Cell membrane.
Reconstitution and Storage-20°C
ImmunogenKLH conjugated synthetic phosphopeptide derived from human LKB1 around the phosphorylation site of Thr363 [IY(p-T)QD]
PurificationProtein A Purified
Concentration1 ug/ul
Intended UseFor research use only. Not intended for diagnostic or therapeutic use.
Application InfoWB: 1:100 - 1000
IHC-P: : 1:100 - 500
Gene SymbolSTK11
Gene Full Nameserine/threonine kinase 11
Alias SymbolshLKB1;liver kinase B1;LKB1;PJS;polarization-related protein LKB1;renal carcinoma antigen NY-REN-19;serine/threonine-protein kinase 11;serine/threonine-protein kinase LKB1;serine/threonine-protein kinase STK11.
NCBI Gene Id6794
Protein NameSerine/threonine-protein kinase STK11
Description of TargetTumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).
Uniprot IDQ15831
  1. What is the species homology for "STK11 Antibody (Phospho-Thr363) (OABF00746)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Bovine|Chicken|Dog|Horse|Human|Mouse|Rat".

  2. How long will it take to receive "STK11 Antibody (Phospho-Thr363) (OABF00746)"?

    This item is available "3 to 5 business days.".

  3. What buffer format is "STK11 Antibody (Phospho-Thr363) (OABF00746)" provided in?

    This item is provided in "Liquid. Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "STK11 Antibody (Phospho-Thr363) (OABF00746)"?

    This target may also be called "hLKB1;liver kinase B1;LKB1;PJS;polarization-related protein LKB1;renal carcinoma antigen NY-REN-19;serine/threonine-protein kinase 11;serine/threonine-protein kinase LKB1;serine/threonine-protein kinase STK11." in publications.

  5. What is the shipping cost for "STK11 Antibody (Phospho-Thr363) (OABF00746)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "STK11 Antibody (Phospho-Thr363) (OABF00746)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "STK11 Antibody (Phospho-Thr363) (OABF00746)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "STK11 Antibody (Phospho-Thr363) (OABF00746)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "STK11"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "STK11"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "STK11"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "STK11"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "STK11"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "STK11"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

Write Your Own Review
You're reviewing:STK11 Antibody (Phospho-Thr363) (OABF00746)
Your Rating
We found other products you might like!