Aviva Systems Biology will be closed in observance of Good Friday 3/29/2024. If you are in need of any assistance please email info@avivasysbio.com

Catalog No: OABF00746-Biotin
Size:100ul
Price: $459.00
SKU
OABF00746-Biotin
Availability: Domestic: within 1 week delivery | International: 1 week
Bulk
Order
Aviva's
Satisfaction
Guarantee
Contact Us:
Shipping Info:
  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
  • Contact us for international orders.

STK11 Antibody (Phospho-Thr363) : Biotin (OABF00746-Biotin)

Datasheets/ManualsPrintable datasheet for OABF00746-Biotin
Product Info
Predicted Species ReactivityHuman, Mouse, Rat
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer.
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationBiotin
ApplicationWB, IHC-P, IF
Additional InformationSubcellular location: Cytoplasm, Nucleus, Mitochondrion, Cell membrane
::Modification: Phosphorylation (Thr363)
Reconstitution and StorageAll conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
ImmunogenKLH conjugated synthetic phosphopeptide derived from human LKB1 around the phosphorylation site of Thr363 [IY(p-T)QD]
PurificationPurified by Protein A.
Concentration1 mg/ml
Application InfoWB(1:100-1000)
IHC-P(1:100-500)
IF(1:50-200)
Gene SymbolSTK11
Gene Full Nameserine/threonine kinase 11
Alias SymbolsPJS, LKB1, hLKB1
NCBI Gene Id6794
Description of TargetTumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Isoform 2: Has a role in spermiogenesis.
Uniprot IDQ15831
  1. What is the species homology for "STK11 Antibody (Phospho-Thr363) : Biotin (OABF00746-Biotin)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "STK11 Antibody (Phospho-Thr363) : Biotin (OABF00746-Biotin)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "STK11 Antibody (Phospho-Thr363) : Biotin (OABF00746-Biotin)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "STK11 Antibody (Phospho-Thr363) : Biotin (OABF00746-Biotin)"?

    This target may also be called "PJS, LKB1, hLKB1" in publications.

  5. What is the shipping cost for "STK11 Antibody (Phospho-Thr363) : Biotin (OABF00746-Biotin)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "STK11 Antibody (Phospho-Thr363) : Biotin (OABF00746-Biotin)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "STK11 Antibody (Phospho-Thr363) : Biotin (OABF00746-Biotin)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "STK11 Antibody (Phospho-Thr363) : Biotin (OABF00746-Biotin)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "STK11"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "STK11"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "STK11"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "STK11"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "STK11"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "STK11"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

Write Your Own Review
You're reviewing:STK11 Antibody (Phospho-Thr363) : Biotin (OABF00746-Biotin)
Your Rating
We found other products you might like!