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SMARCE1 Antibody - N-terminal region (ARP33313_P050)

100 ul

Regular Price: $289.00

Special Price: $229.00

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Conjugation Options

ARP33313_P050-FITC Conjugated

ARP33313_P050-HRP Conjugated

ARP33313_P050-Biotin Conjugated

Tested Species Reactivity:
Human
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
SMARCE1
Official Gene Full Name:
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
NCBI Gene Id:
6605
Protein Name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Swissprot Id:
Q969G3
Protein Accession #:
NP_003070
Nucleotide Accession #:
NM_003079
Alias Symbols:
BAF57
Replacement Item:
This antibody may replace item sc-25140 from Santa Cruz Biotechnology.
Description of Target:
SMARCE1 is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-72 BQ707908.1 667-738 73-2415 AK095047.1 40-2382 2416-2425 BC063700.1 2379-2388
Protein Size (# AA):
411
Molecular Weight:
47kDa
Purification:
Affinity Purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express SMARCE1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express SMARCE1.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human SMARCE1
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 77%; Horse: 92%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 85%; Rat: 93%
Complete computational species homology data:
Anti-SMARCE1 (ARP33313_P050)
Peptide Sequence:
Synthetic peptide located within the following region: EEREKEAAEQAERSQSSIVPEEEQAANKGEEKKDDENIPMETEETHLEET
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
NOTCH2NL; KRTAP10-9; CCDC172; NBPF22P; TXLNA; MIPOL1; KRT40; MRFAP1L1; SYCE1; ING5; USHBP1; CEP70; CEP63; CCDC136; RINT1; TRIM54; AMOTL2; MED4; TFIP11; NUP62; MTUS2; EXOC7; RALBP1; SPAG5; JAKMIP2; TRIP10; STX11; CEP170P1; MEOX2; KRT31; KRT15; KIFC3; GOLGA
Blocking Peptide:
For anti-SMARCE1 (ARP33313_P050) antibody is Catalog # AAPP04355
Datasheets/Manuals:
Printable datasheet for anti-SMARCE1 (ARP33313_P050) antibody
Target Reference:
Pan,H., (2007) Biochim. Biophys. Acta 1772 (9), 1075-1084

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