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Catalog No: OAAB16575
Size:400ul
Price: $450.00
SKU
OAAB16575
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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SIRT3 Antibody - C-terminal region (OAAB16575)

Datasheets/ManualsPrintable datasheet for OAAB16575
Product Info
Predicted Species ReactivityHuman, Mouse
Product FormatLiquid. PBS with 0.09% (W/V) sodium azide
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ApplicationIHC-P, WB
Additional InformationFunction: NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription.
Cellular Location: Mitochondrion matrix.
Tissue Location: Widely expressed.
Reconstitution and StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis SIRT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-279 amino acids from the C-terminal region of human SIRT3.
PurificationThis antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration1.24 mg/ml
Intended UseFor research use only and not for use in diagnostic or therapeutic procedures.
Application InfoWB: 1:1000
IHC-P: 1:50~100
Optimal dilutions should be determined by the end user.
Gene SymbolSIRT3
Alias SymbolsSIR2L3
NCBI Gene Id23410
Protein NameNAD-dependent protein deacetylase sirtuin-3, mitochondrial
Description of TargetSIRT3 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The SIRT3 is included in class I of the sirtuin family.
Uniprot IDQ9NTG7
Protein Accession #NP_001017524.1
Molecular Weight44 kDa
  1. What is the species homology for "SIRT3 Antibody - C-terminal region (OAAB16575)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse".

  2. How long will it take to receive "SIRT3 Antibody - C-terminal region (OAAB16575)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "SIRT3 Antibody - C-terminal region (OAAB16575)" provided in?

    This item is provided in "Liquid. PBS with 0.09% (W/V) sodium azide".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "SIRT3 Antibody - C-terminal region (OAAB16575)"?

    This target may also be called "SIR2L3" in publications.

  5. What is the shipping cost for "SIRT3 Antibody - C-terminal region (OAAB16575)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "SIRT3 Antibody - C-terminal region (OAAB16575)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "SIRT3 Antibody - C-terminal region (OAAB16575)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "44 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "SIRT3 Antibody - C-terminal region (OAAB16575)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "SIRT3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "SIRT3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "SIRT3"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "SIRT3"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "SIRT3"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "SIRT3"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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