SERPINE1 Protein (OPPA01524)

Catalog No: OPPA01524 (Formerly GWB-B1C7EB)

Size:5UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: 150mM Na2HPO4, pH 6.6, 0.5mM NaCl, 2mM Glutathione and 0.01% Tween-80. Physical appearance: Sterile Filtered clear colorless solution.
• Host: E. Coli
  Product Introduction: Plasminogen activator inhibitor-1 is the principal inhibitor of tissue plasminogen activator(tPA) and urokinase(uPA), the activators of plasminogenand hence fibrinolysis(the physiological breakdown of blood clots). It is a serine protease inhibitor(serpin) protein (SERPINE1). The other PAI, plasminogen activator inhibitor-2(PAI-2) is secreted by the placentaand only present in significant amounts during pregnancy. In addition, protease nexinacts as an inhibitor of tPA and urokinase. SERPINE1, however, is the main inhibitor of the plasminogen activators.
  Product Description: SERPINE1 Human Recombinant fused to N-terminal His-Tag produced in E.Coli is a single, non-glycosylated polypeptide chain containing 400 amino acids (24-402) and having a molecular mass of 45 kDa.The SERPINE1 is purified by proprietary chromatographic techniques.
• Reconstitution and Storage: SERPINE1 although stable 10C for 1 week, should be stored desiccated below -18C, -70C is preferred. Please prevent freeze-thaw cycles.
• Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Peptide Sequence: MGSSHHHHHH SSGLVPRGSH MVHHPPSYVA HLASDFGVRV FQQVAQASKD RNVVFSPYGVASVLAMLQLT TGGETQQQIQ AAMGFKIDDK GMAPALRHLY KELMGPWNKD EISTTDAIFVQRDLKLVQGF MPHFFRLFRS TVKQVDFSEV ERARFIINDW VKTHTKGMIS NLLGKGAVDQLTRLVLVNAL YFNGQWKTPF PDSSTHRRLF HKSDGSTVSV PMMAQTNKFN YTEFTTPDGHYYDILELPYH GDTLSMFIAA PYEKEVPLSA LTNILSAQLI SHWKGNMTRL PRLLVLPKFSLETEVDLRKP LENLGMTDMF RQFQADFTSL SDQEPLHVAQ ALQKVKIEVN ESGTVASSSTAVIVSARMAP EEIIMDRPFL FVVRHNPTGT VLFMGQVMEP.

Target Info

• Gene Symbol: SERPINE1
• Alias Symbols: PAI, PAI1, PAI-1, PLANH1
• NCBI Gene Id: 5054
• Protein Name: Plasminogen activator inhibitor 1
• Description of Target: Recobinant Human Plasminogen Activator Inhibitor-1
• Uniprot ID: P05121
• Protein Accession #: NP_000593.1
• Protein Size (# AA): Recombinant