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RHOA Antibody (OAAB21952)

100 ul
$390.00
In Stock
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Predicted Species Reactivity:
Human, Mouse
Product Format:
Liquid
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB, IF, ICC, IHC-P
Additional Information:
Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
RHOA
Official Gene Full Name:
ras homolog family member A
NCBI Gene Id:
387
Swissprot Id:
P61586
Protein Accession #:
NP_001300870.1
Nucleotide Accession #:
NM_001313941.1
Alias Symbols:
ARHA, ARH12, RHO12, RHOH12
Replacement Item:
This antibody may replace item sc-166399 from Santa Cruz Biotechnology.
Description of Target:
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified.
Molecular Weight:
22 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express RHOA.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express RHOA.
Predicted Homology Based on Immunogen Sequence:
Human, Mouse
Datasheets/Manuals:
Printable datasheet for anti-RHOA (OAAB21952) antibody
Preservative:
0.03% Proclin300 and 50% glycerol
Formulation:
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Application Info:
FC: 1:20~1:100
WB: 1:100~1:500
IHC-P: 1:100~1:500

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