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LMNA Antibody (OAGA01482)

100 ul
$409.00
In Stock
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Predicted Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid. 1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Application:
IF, IHC-P, IP, WB
Reconstitution and Storage:
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Gene Symbol:
LMNA
Official Gene Full Name:
lamin A/C
NCBI Gene Id:
4000
Swissprot Id:
P02545
Alias Symbols:
FPL, IDC, LFP, CDDC, EMD2, FPLD, HGPS, LDP1, LMN1, LMNC, PRO1, CDCD1, CMD1A, FPLD2, LMNL1, CMT2B1, LGMD1B
Replacement Item:
This antibody may replace item sc-177453 from Santa Cruz Biotechnology.
Description of Target:
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Purification:
Purified by antigen-affinity chromatography.
Tissue Tool:
Find tissues and cell lines supported to express LMNA.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express LMNA.
Immunogen:
Recombinant protein encompassing a sequence within the center region of human Lamin A/C. The exact sequence is proprietary.
Concentration:
1.23mg/ml
Datasheets/Manuals:
Printable datasheet for anti-LMNA (OAGA01482) antibody
Application Info:
Suggested starting dilutions are as follows: WB: 1:500-1:3000, IHC-P: 1:100-1:1000, ICC/IF: 1:100-1:1000, IP: 1:100-1:500. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

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