LMNA Antibody (OAAB21401)

Catalog No: OAAB21401

Size:100ul

Western blot detection of Lamin A in K562, C6, 3T3 and Hela cell lysates using Lamin A mouse mAb (OAAB21401) (1:1,000 diluted). Predicted band size: 74KDa. Observed band size: 74KDa.

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid
• Clonality: Monoclonal
• Host: Mouse
• Application: WB
• Additional Information: Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Predicted Homology Based on Immunogen Sequence: Human, Mouse
• Preservative: 0.03% Proclin300 and 50% glycerol
• Formulation: 0.03% Proclin300 and 50% glycerol.
• Application Info: WB: 1:1000
• Reference: McKeon F.D.,et al.Nature 319:463-468(1986).
  Fisher D.Z.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:6450-6454(1986).
  Sylvius N.,et al.J. Med. Genet. 42:639-647(2005).
  Csoka A.B.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
  Ota T.,et al.Nat. Genet. 36:40-45(2004).
  

Target Info

• Gene Symbol: LMNA
• Gene Full Name: lamin A/C
• Alias Symbols: FPL, IDC, LFP, CDDC, EMD2, FPLD, HGPS, LDP1, LMN1, LMNC, MADA, PRO1, CDCD1, CMD1A, FPLD2, LMNL1, CMT2B1, LGMD1B
• NCBI Gene Id: 4000
• Description of Target: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
• Uniprot ID: P02545
• Protein Accession #: NP_001244303.1
• Nucleotide Accession #: NM_001257374.2
• Molecular Weight: 74 kDa