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LGALS3 Antibody - N-terminal region (ARP54688_P050)

100 ul
$289.00
In Stock
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Conjugation Options

ARP54688_P050-FITC Conjugated

ARP54688_P050-HRP Conjugated

ARP54688_P050-Biotin Conjugated

Gene Symbol:
LGALS3
NCBI Gene Id:
3958
Official Gene Full Name:
galectin 3
Protein Name:
galectin-3
Swissprot Id:
P17931
Protein Accession #:
NP_002297
Nucleotide Accession #:
NM_002306
Alias Symbols:
L31, GAL3, MAC2, CBP35, GALBP, GALIG, LGALS2
Replacement Item:
This antibody may replace item sc-155994 from Santa Cruz Biotechnology.
Description of Target:
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.
Protein Size (# AA):
250
Molecular Weight:
26kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express LGALS3.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express LGALS3.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human LGALS3
Tested Species Reactivity:
Human, Mouse
Predicted Homology Based on Immunogen Sequence:
Cow: 93%; Dog: 93%; Guinea Pig: 92%; Horse: 92%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 92%; Rat: 93%
Complete computational species homology data:
Anti-LGALS3 (ARP54688_P050)
Peptide Sequence:
Synthetic peptide located within the following region: GASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPG
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
PRR13; SS18L1; PPIG; LGALS3; GOLGA2; MAP1LC3A; SQSTM1; RAB7A; LAMP1; EGFR; CFTR; PAXIP1; BARD1; AGPS; IGBP1; GTF2I; CLNS1A; APP; SLC25A5; ACTA1; MYOC; LGALS3BP; CYHR1; GEMIN4; SUFU; CUBN; CSNK1A1; LIM2; FCGR2A; ELN; MMP2; CSNK2A2; CSNK2A1; C1GALT1C1; LGAL
Blocking Peptide:
For anti-LGALS3 (ARP54688_P050) antibody is Catalog # AAP54688 (Previous Catalog # AAPP31479)
Datasheets/Manuals:
Printable datasheet for anti-LGALS3 (ARP54688_P050) antibody
Sample Type Confirmation:

LGALS3 is supported by BioGPS gene expression data to be expressed in MCF7

Additional Information:
IHC Information: Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Target Reference:
Bartolazzi,A., (2008) Lancet Oncol. 9 (6), 543-549
Publications:

Guha, P. et al. Nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell-like properties via a signaling cascade involving galectin-3, -alpha9 nicotinic acetylcholine receptor and STAT3. Breast Cancer Res. Treat. 145, 5-22 (2014). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat 24668500

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