| Product Number |
ARP54688_P050 |
| Product Page |
www.avivasysbio.com/lgals3-antibody-n-terminal-region-arp54688-p050.html |
| Name |
LGALS3 Antibody - N-terminal region (ARP54688_P050) |
| Protein Size (# AA) |
250 amino acids |
| Molecular Weight |
26kDa |
| NCBI Gene Id |
3958 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
galectin 3 |
| Alias Symbols |
L31, GAL3, MAC2, CBP35, GALBP, GALIG, LGALS2 |
| Peptide Sequence |
Synthetic peptide located within the following region: GASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPG |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Bartolazzi,A., (2008) Lancet Oncol. 9 (6), 543-549 |
| Description of Target |
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants. |
| Protein Interactions |
PRR13; SS18L1; PPIG; LGALS3; GOLGA2; MAP1LC3A; SQSTM1; RAB7A; LAMP1; EGFR; CFTR; PAXIP1; BARD1; AGPS; IGBP1; GTF2I; CLNS1A; APP; SLC25A5; ACTA1; MYOC; LGALS3BP; CYHR1; GEMIN4; SUFU; CUBN; CSNK1A1; LIM2; FCGR2A; ELN; MMP2; CSNK2A2; CSNK2A1; C1GALT1C1; LGAL |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-LGALS3 (ARP54688_P050) antibody |
| Additional Information |
IHC Information: Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) |
| Blocking Peptide |
For anti-LGALS3 (ARP54688_P050) antibody is Catalog # AAP54688 (Previous Catalog # AAPP31479) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human LGALS3 |
| Uniprot ID |
P17931 |
| Protein Name |
galectin-3 |
| Publications |
Guha, P. et al. Nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell-like properties via a signaling cascade involving galectin-3, a9 nicotinic acetylcholine receptor and STAT3. Breast Cancer Res. Treat. 145, 5-22 (2014). 24668500 |
| Sample Type Confirmation |
LGALS3 is supported by BioGPS gene expression data to be expressed in MCF7 |
| Protein Accession # |
NP_002297 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_002306 |
| Tested Species Reactivity |
Human, Mouse |
| Gene Symbol |
LGALS3 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 93%; Guinea Pig: 92%; Horse: 92%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 92%; Rat: 93% |
| Image 1 | Human Small Intestine
 | Human Small Intestine |
|
| Image 2 | Human Fetal Lung
 | WB Suggested Anti-LGALS3 Antibody Titration: 1 ug/ml
Positive Control: Fetal Lung cell lysate |
|
| Image 3 | Mouse Testis
 | Host: Mouse
Target Name: LGALS3
Sample Tissue: Mouse Testis
Antibody Dilution: 1ug/ml |
|
| Image 4 | Human Fetal Heart
 | Host: Rabbit
Target Name: LGALS3
Sample Type: Human Fetal Heart
Antibody Dilution: 1.0ug/ml |
|
| Image 5 | Human MCF7
 | Host: Rabbit
Target Name: LGALS3
Sample Type: MCF7
Antibody Dilution: 1.0ug/mlLGALS3 is supported by BioGPS gene expression data to be expressed in MCF7 |
|
