KISS1R Antibody (OABF00997)

Catalog No: OABF00997

Size:100UL

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Formalin-fixed and paraffin embedded rat ovarian tissue labeled with Anti-KiSS1 receptor Polyclonal Antibody, Unconjugated (OABF00997) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Product Info

• Predicted Species Reactivity: Dog|Guinea Pig|Human|Mouse|Other|Porcine|Rat|Sheep
• Product Format: Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot
• Additional Information: Subcellular location: Cytoplasm
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from human KiSS1 receptor
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: WB: 1:100 - 1000
  IHC-P: : 1:100 - 500

Target Info

• Gene Symbol: KISS1R
• Gene Full Name: KISS1 receptor
• Alias Symbols: AXOR12;CPPB1;G protein-coupled receptor 54;GPR54;G-protein coupled receptor 54;G-protein coupled receptor OT7T175;HH8;HOT7T175;hypogonadotropin-1;kiSS-1 receptor;KISS-1R;kisspeptins receptor;metastin receptor.
• NCBI Gene Id: 84634
• Protein Name: KiSS-1 receptor
• Description of Target: Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.
• Uniprot ID: Q969F8