KISS1R Antibody (OAAF04973)

Catalog No: OAAF04973 (Formerly GWB-ASF365)

Size:100 ug

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Immunofluorescence analysis of LOVO cells, using KISS1R Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human KISS1R.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: KISSR antibody detects endogenous levels of total KISSR protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: IF: 1:100~1:500; ELISA: 1:5000
• Reference: Ohtaki T., Nature 411:613-617(2001).
  Clements M.K., Biochem. Biophys. Res. Commun. 284:1189-1193(2001).
  Muir A.I., J. Biol. Chem. 276:28969-28975(2001).

Target Info

• Gene Symbol: KISS1R
• Gene Full Name: KISS1 receptor
• Alias Symbols: AXOR12;CPPB1;G protein-coupled receptor 54;GPR54;G-protein coupled receptor 54;G-protein coupled receptor OT7T175;HH8;HOT7T175;hypogonadotropin-1;kiSS-1 receptor;KISS-1R;kisspeptins receptor;metastin receptor.
• NCBI Gene Id: 84634
• Protein Name: KiSS-1 receptor
• Description of Target: Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.
• Uniprot ID: Q969F8
• Protein Accession #: NP_115940.2
• Molecular Weight: 42 kDa