Human BDNF Protein (OPSA11059)

Catalog No: OPSA11059 (Formerly GWB-DE906C)

Size:10UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Lyophilized
• Application: Functional assay
• Additional Information: Endotoxin Level: < 1EU/ug
  Carrier Free: Yes
• Reconstitution and Storage: -20°C
• Purification: Purified recombinant BDNF expressed in E.coli
• Concentration: 0.1 mg/ml
• Preparation: Purified recombinant BDNF expressed in E.coli.
• Purity: >98% by SDS PAGE and HPLC analysis
• Biological Activity: Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED₅₀ for this effect is 0.5-1.0 ug/ml.
• Specificity: BDNF (brain-derived neurotrophic factor) is a potent neurotrophin and member of the NGF-beta family, secreted from dense core vesicles, which promotes the growth, differentiation and survival of neurons within, or directly connected to, the central nervous system (CNS).
  BDNF signals through binding to the high affinity receptor trkB, and also binds to the low affinity neurotrophin receptor LNGFR. Studies have shown the involvement of BDNF in the modulation of short-term synaptic function and in the formation of long-term memory, and reduced levels of BDNF are seen in patients with Alzheimer's and Huntington disease.
  

Target Info

• Gene Symbol: BDNF
• Alias Symbols: ANON2, BULN2
• NCBI Gene Id: 627
• Protein Name: Brain-derived neurotrophic factor
• Description of Target: RECOMBINANT HUMAN BDNF
  
• Uniprot ID: P23560
• Protein Accession #: NP_001137277.1
• Protein Size (# AA): Recombinant
• Molecular Weight: 27.0 kDa (119 amino acid homodimer)