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BDNF Antibody - C-terminal region (OAAB05026)

400ul
$390.00
In Stock
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Gene Symbol:
BDNF
NCBI Gene Id:
627
Protein Name:
Brain-derived neurotrophic factor
Swissprot Id:
P23560
Protein Accession #:
NP_001137277.1
Alias Symbols:
Brain-derived neurotrophic factor, BDNF, Abrineurin
Replacement Item:
This antibody may replace item sc-20981 from Santa Cruz Biotechnology.
Description of Target:
BDNF is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this protein is reduced in both Alzheimer's and Huntington disease patients. This protein may play a role in the regulation of stress response and in the biology of mood disorders.
Molecular Weight:
27818 Da
Host:
Rabbit
Clonality:
Polyclonal
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Application:
WB, IHC-P, FC, IF
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express BDNF.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express BDNF.
Immunogen:
This BDNF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-236 amino acids from the C-terminal region of human BDNF.
Predicted Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Bovine, Mouse, Pig, Rat
Product Format:
Liquid. PBS with 0.09% (W/V) sodium azide.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals:
Printable datasheet for anti-BDNF antibody - OAAB05026
Isotype:
Ig
Intended Use:
For research use only and not for use in diagnostic or therapeutic procedures.
Application Info:
WB: 1:1000
IHC-P: 1:10~50
IF: 1:10~50
FC: 1:10~50
Additional Information:
Function: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Cellular Location: Secreted.
Tissue Location: Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta

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