Catalog No: OPED00065
Size:50 ug
Price: $370.00
SKU
OPED00065
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HSPB1 Recombinant Protein (Human) (OPED00065)

Hsp27 is one of the most common members of the highly conserved and ubiquitously expressed family of small heat shock proteins (sHsp), which also includes alpha B-crystallin. It is characterized by a conserved C-terminal alpha -crystallin domain consisting of two anti-parallel beta -sheets that promote oligomer formation required for its primary chaperone function as inhibitor of irreversible protein aggregation. Hsp27 oligomerization is modulated by post-translational phosphorylation of Hsp27 at three serine residues, Ser15, Ser78, and Ser82, by a variety of protein kinases including MAPKAPK-3, PKAc-alpha , p70 S6K, PKD I, and PKC-delta. Hsp27 has been shown to inhibit actin polymerization by binding of unphosphorylated Hsp27 monomers to actin intermediate filaments. Anti-apoptotic functions of Hsp27 have also been identified through interactions with DAXX7, activation of Akt, and inhibition of apoptosome formation. Evidence suggests altered expression of Hsp27 is implicated in the pathogenesis of breast, ovarian, and prostate cancer.
Datasheets/ManualsPrintable datasheet for OPED00065
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid 1X Dulbecco's PBS
HostE. Coli
ApplicationWB
Additional InformationEndotoxin Level: < 50 EU/mg purified protein (LAL test)
Reconstitution and StorageStore at -80°C. Avoid repeated freeze/thaw cycles.
PurificationPurified by multi-step chromatography.
ConcentrationVaries by lot. See vial for concentration.
Purity≥ 95% (SDS-PAGE, Western blot)
SpecificityImmunoreactive with antibody specific for Hsp27
Application InfoWestern blot control.
Gene SymbolHSPB1
Gene Full Nameheat shock protein family B (small) member 1
Alias SymbolsCMT2F, HMN2B, HSP27, HSP28, Hsp25, SRP27, HS.76067, HEL-S-102
NCBI Gene Id3315
Protein NameHeat shock protein beta -1
Description of TargetThe protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN).
Uniprot IDP04792
Protein Accession #NP_001138610.1
Nucleotide Accession #NM_001145138.1
Protein Size (# AA)205
Molecular Weight27 kDa
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