HSPB1 Antibody - C-terminal region (ARP30177_T100)

Size:100 ul

Human HepG2

Human kidney

Human Heart Muscle

Basic Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: IHC, WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Replacement Item: This antibody may replace item sc-1048 from Santa Cruz Biotechnology.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HSPB1
• Purification: Protein A purified
• Predicted Homology Based on Immunogen Sequence: Human: 100%
• Complete computational species homology data: Anti-HSPB1 (ARP30177_T100)
• Peptide Sequence: Synthetic peptide located within the following region: SLSPEGTLTVEAPMPKLATQSNEITIPVTFESRAQLGGPEAAKSDETAAK
• Concentration: Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
• Blocking Peptide: For anti-HSPB1 (ARP30177_T100) antibody is Catalog # AAP30177 (Previous Catalog # AAPS08907)
• Datasheets/Manuals: Printable datasheet for anti-HSPB1 (ARP30177_T100) antibody
• Target Reference: Boncinelli,E., (2006) J. Biol. Chem. 281 (12), 8169-8174
• Publications:

  Narjoz, C. et al. Genomic consequences of cytochrome P450 2C9 overexpression in human hepatoma cells. Chem. Res. Toxicol. 22, 779-87 (2009). IHC, WB, Human 19445531

  Sookoian, S; Castaño, GO; Scian, R; San Martino, J; Pirola, CJ; Heat Shock Protein 27 is down-regulated in Ballooned Hepatocytes of Patients with Nonalcoholic Steatohepatitis (NASH). 6, 22528 (2016). IHC, WB, Human 26935030

Target Info

• Gene Symbol: HSPB1
• Official Gene Full Name: Heat shock 27kDa protein 1
• Alias Symbols: CMT2F, DKFZp586P1322, HS.76067, HSP27, HSP28, Hsp25, HMN2B, SRP27
• NCBI Gene Id: 3315
• Protein Name: Heat shock protein beta-1
• Description of Target: HSPB1, like the other heat shock proteins, is part of a complex system of molecular chaperones in epidermal keratinocytes.
• Swissprot Id: P04792
• Protein Accession #: NP_001531
• Nucleotide Accession #: NM_001540
• Protein Size (# AA): 205
• Molecular Weight: 23kDa
• Tissue Tool: Find tissues and cell lines supported by DNA array analysis to express HSPB1.
• RNA Seq: Find tissues and cell lines supported by RNA-seq analysis to express HSPB1.
• Protein Interactions: PCSK9; HUWE1; UBC; GATA1; MAPKAPK2; AKT1; CRYAB; MAP3K7; SUMO2; HAUS1; CEP57; AARSD1; BAG3; IRS4; HSF1; LCE3A; TGFB1I1; SUMO1; NEDD8; MDM2; ASB6; ASB10; ASB17; WWOX; ASB4; ZBTB1; RPA3; RPA2; RPA1; EZH2; ESR1; SOX2; NPM1; PLG; CS; MAPKAPK3; INS; HSPB1; SGA