- Gene Symbol:
- HSPB1
- NCBI Gene Id:
- 3315
- Official Gene Full Name:
- Heat shock 27kDa protein 1
- Protein Name:
- Heat shock protein beta-1
- Swissprot Id:
- P04792
- Protein Accession #:
- NP_001531
- Nucleotide Accession #:
- NM_001540
- Alias Symbols:
- CMT2F, DKFZp586P1322, HS.76067, HSP27, HSP28, Hsp25, HMN2B, SRP27
- Replacement Item:
- This antibody may replace item sc-1048 from Santa Cruz Biotechnology.
- Description of Target:
- HSPB1, like the other heat shock proteins, is part of a complex system of molecular chaperones in epidermal keratinocytes.
- Protein Size (# AA):
- 205
- Molecular Weight:
- 23kDa
- Host:
- Rabbit
- Clonality:
- Polyclonal
- Purification:
- Protein A purified
- Application:
- IHC, WB
- Tissue Tool:
- Find tissues and cell lines supported by DNA array analysis to express HSPB1.
- RNA Seq:
- Find tissues and cell lines supported by RNA-seq analysis to express HSPB1.
- Immunogen:
- The immunogen is a synthetic peptide directed towards the C terminal region of human HSPB1
- Tested Species Reactivity:
- Human
- Predicted Homology Based on Immunogen Sequence:
- Human: 100%
- Complete computational species homology data:
- Anti-HSPB1 (ARP30177_T100)
- Peptide Sequence:
- Synthetic peptide located within the following region: SLSPEGTLTVEAPMPKLATQSNEITIPVTFESRAQLGGPEAAKSDETAAK
- Product Format:
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
- Reconstitution and Storage:
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
- Concentration:
- Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
- Protein Interactions:
- PCSK9; HUWE1; UBC; GATA1; MAPKAPK2; AKT1; CRYAB; MAP3K7; SUMO2; HAUS1; CEP57; AARSD1; BAG3; IRS4; HSF1; LCE3A; TGFB1I1; SUMO1; NEDD8; MDM2; ASB6; ASB10; ASB17; WWOX; ASB4; ZBTB1; RPA3; RPA2; RPA1; EZH2; ESR1; SOX2; NPM1; PLG; CS; MAPKAPK3; INS; HSPB1; SGA
- Blocking Peptide:
- For anti-HSPB1 (ARP30177_T100) antibody is Catalog # AAP30177 (Previous Catalog # AAPS08907)
- Datasheets/Manuals:
- Printable datasheet for anti-HSPB1 (ARP30177_T100) antibody
- Target Reference:
- Boncinelli,E., (2006) J. Biol. Chem. 281 (12), 8169-8174
- Publications:
Narjoz, C. et al. Genomic consequences of cytochrome P450 2C9 overexpression in human hepatoma cells. Chem. Res. Toxicol. 22, 779-87 (2009). IHC, WB, Human 19445531
Sookoian, S; Castaño, GO; Scian, R; San Martino, J; Pirola, CJ; Heat Shock Protein 27 is down-regulated in Ballooned Hepatocytes of Patients with Nonalcoholic Steatohepatitis (NASH). 6, 22528 (2016). IHC, WB, Human 26935030
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