FOLR1 Antibody - middle region (OASG02825)

Catalog No: OASG02825

Size:100 uL

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB
• Additional Information: Cellular Location: Cell membrane. Lipid-anchor, GPI-anchor. Secreted Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane. Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane.
  Tissue Specificity: Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the Internal region of human FR- Alpha. Location: 10-90aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
• Specificity: FR- Alpha Polyclonal Antibody detects endogenous levels of FR- Alpha protein.
• Application Info: WB: 1:500~2000
  ELISA: 1:5000

Target Info

• Gene Symbol: FOLR1
• Gene Full Name: folate receptor 1 (adult)
• Alias Symbols: FBP, FOLR, NCFTD, FRalpha
• NCBI Gene Id: 2348;
• Description of Target: The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
• Uniprot ID: P15328, P35846
• Molecular Weight: 34 kDa