DNMT3B Antibody (OABF00118)

Catalog No: OABF00118

Size:100UL

Formalin-fixed and paraffin embedded: human colon cancer tissue labeled with Anti-Dnmt-3-beta Polyclonal Antibody, Unconjugated (OABF00118) at 1:600, followed by conjugation to the secondary antibody and DAB staining

Formalin-fixed and paraffin embedded: rat spinal cord tissue labeled with Anti-Dnmt-3-beta Polyclonal Antibody (OABF00118), Unconjugated at 1:600, followed by conjugation to the secondary antibody and DAB staining

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
• Additional Information: Subcellular location: Nucleus
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from human Dnmt3 Beta
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: WB: 1:100 - 1000
  IHC-P: : 1:100 - 500

Target Info

• Gene Symbol: DNMT3B
• Gene Full Name: DNA methyltransferase 3 beta
• Alias Symbols: DNA (cytosine-5-)-methyltransferase 3 beta;DNA (cytosine-5)-methyltransferase 3B;DNA cytosine-5--methyltransferase 3 beta;DNA methyltransferase HsaIIIB;DNA MTase HsaIIIB;FSHD4;ICF;ICF1;M.HsaIIIB.
• NCBI Gene Id: 1789
• Protein Name: DNA (cytosine-5)-methyltransferase 3B
• Description of Target: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398).
• Uniprot ID: Q9UBC3