DNMT3B Antibody - N-terminal region (OASG02207)

Catalog No: OASG02207

Size:100 uL

Western Blot using HT29

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC, IF
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the N-terminal region of human Dnmt3b. Location: 1-80aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Specificity: Dnmt3b Polyclonal Antibody detects endogenous levels of Dnmt3b protein.
• Application Info: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000;

Target Info

• Gene Symbol: DNMT3B
• Gene Full Name: DNA (cytosine-5-)-methyltransferase 3 beta
• Alias Symbols: ICF, ICF1, M.HsaIIIB
• NCBI Gene Id: 1789;
• Description of Target: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
• Uniprot ID: Q9UBC3
• Molecular Weight: 96 kDa