DNM1L Antibody - N-terminal (OAPB01835)

Catalog No: OAPB01835

Size:100UG

Western blot analysis of DNM1L in HeLa cell lysate with DNM1L antibody at 1 ug/ml.

Product Info

• Predicted Species Reactivity: Bovine|Human|Mouse|Rat
• Product Format: Liquid. DNM1L antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Western blot
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: DNM1L antibody was raised against a 19 amino acid peptide near the center of human DNM1L. The immunogen is located within amino acids 530 - 580 of DNM1L.
• Purification: Affinity Purified
• Concentration: 1 mg/ml

Target Info

• Gene Symbol: DNM1L
• Gene Full Name: dynamin 1 like
• Alias Symbols: DLP1;Dnm1p/Vps1p-like protein;DRP1;DVLP;DYMPLE;dynamin family member proline-rich carboxyl-terminal domain less;dynamin-1-like protein;Dynamin-like protein;dynamin-like protein 4;dynamin-like protein IV;dynamin-related protein 1;EMPF;EMPF1;HDYNIV;OPA5.
• NCBI Gene Id: 10059
• Protein Name: Dynamin-1-like protein|dynamin-1-like protein isoform 1 [Homo sapiens]
• Description of Target: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Plays an important role in mitochondrial fission during mitosis (PubMed:26992161). Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution.
• Uniprot ID: O00429
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_036192
• Nucleotide Accession #: NM_001278463.1
• Molecular Weight: Predicted: 81 kDa Observed: 80 kDa